Browsing ETD: Electronic Theses and Dissertations by Author "Van Stipdonk, Michael J."
Now showing items 1-8 of 8
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Computional chemistry studies of gas-phase ion structures
Kullman, Michael J. (Wichita State University, 2012-05)Computational chemistry and mass spectrometry are two extremely useful tools that when used in conjunction with each other allow detailed knowledge of the gas-phase ions. To that end, computational chemistry, specifically ... -
Detection and quantification of ketamine and clomiphene in complex matrices by LC and ESI-MSN
Lygrisse, Justin (Wichita State University, 2009-05)The research presented here details the development of two separate methods for ESI-MS and LC. The first chapter gives an introduction to the first of the methods presented here, the detection of ketamine in alcoholic ... -
Development of a method to investigate intra-molecular proton migration during collision induced dissociation of gas-phase peptides
Wu, Qun (2005-12)Use of a combination of hydrogen/deuterium (H/D) exchange, mass spectrometry (MS) and/or CID is a rapidly evolving approach to the investigation of protein structure and conformation and the dynamics of conformational ... -
Fragmentation of model peptides by collision-activated dissociation
Cooper, Travis J. (Wichita State University, 2009-07)Novel fragmentation pathways of various model peptides were generated by collision-induced dissociation (CID) mass spectrometry. For the series AXAG where X=ßA, γAbu, εCap, or 4AMBz, the CID of the [b₃-1+Cat]⁺ where the ... -
The influence of cation and “alternative” amino acids on the fragmentation pathways of metal cationized and protonated peptides
Ochola, Sila O. (Wichita State University, 2008-05)Tandem mass spectrometry and collision-induced dissociation (CID) are the “workhorse” methods for protein identification in proteomics investigations. Recent studies have demonstrated significant differences in the CID ... -
Investigation of gas-phase metal ion complexes using infrared multiple photon dissociation spectroscopy and density functional theory calculations
Dain, Ryan P. (Wichita State University, 2010-05)A combination of theoretical chemistry and “action” spectroscopy has become the most used tool for the exploration of gas-phase molecular ions. In this study, density functional theory (DFT) calculations were used to ... -
Investigation of uranium and various ligand complexes in the gas phase using electrospray ionization ion trap mass spectrometry
Chien, Wen-Fang Winnie (Wichita State University, 2007-12)The speciation and reactivity of uranium is a topic of sustained interest because species dependent chemistry controls processes ranging from nuclear fuel processing to mobility and fate in the geological surface. Past ... -
McLafferty rearrangement of peptides and substituent effects on peptide fragmentation: Theoretical and experimental investigation
Kerstetter, Dale R. (Wichita State University, 2009-12)The research presented here details two studies that utilized theoretical analysis and experimentation to further the understading of peptide fragmentation. The first study was the McLafferty rearrangement, which involves ...