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dc.contributor.authorKullman, Michael J.
dc.contributor.authorMolesworth, Samuel P.
dc.contributor.authorBerden, Giel
dc.contributor.authorOomens, Jos
dc.contributor.authorVan Stipdonk, Michael J.
dc.date.accessioned2012-06-19T19:37:29Z
dc.date.available2012-06-19T19:37:29Z
dc.date.issued2012-02
dc.identifier.citationKullman, Michael J.; Molesworth, Samuel P.; Berden, Giel; Oomens, Jos & Michael, Van Stipdonk. 2012. IRMPD spectroscopy b2 ions from protonated tripeptides with 4-aminomethyl benzoic acid residues. International Journal of Mass Spectrometry. 9 February 2012.en_US
dc.identifier.issn1387-3806
dc.identifier.urihttp://hdl.handle.net/10057/5170
dc.identifier.urihttp://dx.doi.org/10.1016/j.ijms.2012.01.008
dc.descriptionClick on the DOI link below to access the article (may not be free).en_US
dc.description.abstractCollision-induced dissociation (CID) of the peptide alanine-4-aminomethylbenzoic acid-glycine, A(AMBz)G generates a prominent b2 ion despite a previous report [E.R. Talaty, T.J. Cooper, S.M. Osburn, M.J. Van Stipdonk, Collision-induced dissociation of protonated tetrapeptides containing β-alanine, γ-aminobutyric acid, É-aminocaproic acid or 4-aminomethylbenzoic acid residues, Rapid Commun. Mass Spectrom. 20 (2006) 3443–3455.] which showed that incorporation of the aromatic amino acid into a peptide sequence inhibits generation of bn ions formed by cleavage to the immediate C-terminal side of the residue. Infrared multiple photon dissociation (IRMPD) spectroscopy and density functional theory (DFT) calculations suggest that the b2 ion generated from A(AMBz)G has an acylium structure. The b2 ion generated from (AMBz)AG, in which the aromatic residue is situated at the amino-terminus, is instead a conventional oxazolone. ⺠Infrared multiple photon dissociation (IRMPD) spectroscopy and density functional theory (DFT) calculations used to study fragmentation of peptides that contain 4-aminomethylbenzoic acid residues. ⺠Dominant product ion from protonated AAG, A(AMBz)G and (AMBz)AG is b2+. ⺠IRMPD and DFT calculations suggest that the b2 ion generated from A(AMBz)G has an acylium structure while b2 ion from (AMBz)AG is instead a conventional oxazolone.en_US
dc.language.isoen_USen_US
dc.publisherElsevieren_US
dc.relation.ispartofseriesInternational Journal of Mass Spectrometry;2012
dc.subjectESIen_US
dc.subjectIRMPD spectroscopyen_US
dc.subjectPeptide fragmentationen_US
dc.subjectIon structureen_US
dc.titleIRMPD spectroscopy b2 ions from protonated tripeptides with 4-aminomethyl benzoic acid residuesen_US
dc.typeArticleen_US
dc.description.versionPeer reviewed
dc.rights.holderCopyright © 2012, Elsevier


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