| dc.contributor.author | Mandadapu, Sivakoteswara Rao | |
| dc.contributor.author | Weerawarna, Pathum M. | |
| dc.contributor.author | Gunnam, Mallikarjuna Reddy | |
| dc.contributor.author | Alliston, Kevin R. | |
| dc.contributor.author | Lushington, Gerald H. | |
| dc.contributor.author | Kim, Yunjeong | |
| dc.contributor.author | Chang, Kyeong-Ok | |
| dc.contributor.author | Groutas, William C. | |
| dc.date.accessioned | 2012-06-01T15:49:32Z | |
| dc.date.available | 2012-06-01T15:49:32Z | |
| dc.date.issued | 2012-05-26 | |
| dc.identifier.citation | Mandadapu, Sivakoteswara Rao; Weerawarna, Pathum M. ; Gunnam, Mallikarjuna Reddy; Alliston, Kevin R.; Lushington, Gerald H.; Kim, Yunjeong; Chang, Kyeong-Ok & William C., Groutas. (2012).Potent Inhibition of Norovirus 3CL Protease by Peptidyl α-Ketoamides and α-Ketoheterocycles. Bioorganic & Medicinal Chemistry Letters, Available online 26 May 2012 | en_US |
| dc.identifier.issn | 0960-894X | |
| dc.identifier.issn | 1464-3405 | |
| dc.identifier.uri | http://hdl.handle.net/10057/5111 | |
| dc.identifier.uri | http://dx.doi.org/10.1016/j.bmcl.2012.05.055 | |
| dc.description | Click on the DOI link below to access the article (may not be free). | en_US |
| dc.description.abstract | A series of structurally-diverse α-ketoamides and α-ketoheterocycles was synthesized and subsequently investigated for inhibitory activity against norovirus 3CL protease in vitro, as well as anti-norovirus activity in a cell-based replicon system. The synthesized compounds were found to inhibit norovirus 3CL protease in vitro and to also exhibit potent anti-norovirus activity in a cell-based replicon system. | en_US |
| dc.language.iso | en_US | en_US |
| dc.publisher | Elsevier | en_US |
| dc.relation.ispartofseries | Bioorganic & Medicinal Chemistry Letters;Available online 26 May 2012 | |
| dc.subject | Norovirus 3CL protease | en_US |
| dc.subject | Transition state inhibitors | en_US |
| dc.title | Potent inhibition of norovirus 3CL protease by peptidyl α-ketoamides and α-ketoheterocycles | en_US |
| dc.type | Article | en_US |
| dc.description.version | Peer reviewed accepted manuscript | |
| dc.rights.holder | Copyright Elsevier, 2012 | |
