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dc.contributor.authorMandadapu, Sivakoteswara Rao
dc.contributor.authorWeerawarna, Pathum M.
dc.contributor.authorGunnam, Mallikarjuna Reddy
dc.contributor.authorAlliston, Kevin R.
dc.contributor.authorLushington, Gerald H.
dc.contributor.authorKim, Yunjeong
dc.contributor.authorChang, Kyeong-Ok
dc.contributor.authorGroutas, William C.
dc.date.accessioned2012-06-01T15:49:32Z
dc.date.available2012-06-01T15:49:32Z
dc.date.issued2012-05-26
dc.identifier.citationMandadapu, Sivakoteswara Rao; Weerawarna, Pathum M. ; Gunnam, Mallikarjuna Reddy; Alliston, Kevin R.; Lushington, Gerald H.; Kim, Yunjeong; Chang, Kyeong-Ok & William C., Groutas. (2012).Potent Inhibition of Norovirus 3CL Protease by Peptidyl α-Ketoamides and α-Ketoheterocycles. Bioorganic & Medicinal Chemistry Letters, Available online 26 May 2012en_US
dc.identifier.issn0960-894X
dc.identifier.issn1464-3405
dc.identifier.urihttp://hdl.handle.net/10057/5111
dc.identifier.urihttp://dx.doi.org/10.1016/j.bmcl.2012.05.055
dc.descriptionClick on the DOI link below to access the article (may not be free).en_US
dc.description.abstractA series of structurally-diverse α-ketoamides and α-ketoheterocycles was synthesized and subsequently investigated for inhibitory activity against norovirus 3CL protease in vitro, as well as anti-norovirus activity in a cell-based replicon system. The synthesized compounds were found to inhibit norovirus 3CL protease in vitro and to also exhibit potent anti-norovirus activity in a cell-based replicon system.en_US
dc.language.isoen_USen_US
dc.publisherElsevieren_US
dc.relation.ispartofseriesBioorganic & Medicinal Chemistry Letters;Available online 26 May 2012
dc.subjectNorovirus 3CL proteaseen_US
dc.subjectTransition state inhibitorsen_US
dc.titlePotent inhibition of norovirus 3CL protease by peptidyl α-ketoamides and α-ketoheterocyclesen_US
dc.typeArticleen_US
dc.description.versionPeer reviewed accepted manuscript
dc.rights.holderCopyright Elsevier, 2012


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