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    Potent inhibition of norovirus 3CL protease by peptidyl α-ketoamides and α-ketoheterocycles

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    Article (1.158Mb)
    Date
    2012-05-26
    Author
    Mandadapu, Sivakoteswara Rao
    Weerawarna, Pathum M.
    Gunnam, Mallikarjuna Reddy
    Alliston, Kevin R.
    Lushington, Gerald H.
    Kim, Yunjeong
    Chang, Kyeong-Ok
    Groutas, William C.
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    Citation
    Mandadapu, Sivakoteswara Rao; Weerawarna, Pathum M. ; Gunnam, Mallikarjuna Reddy; Alliston, Kevin R.; Lushington, Gerald H.; Kim, Yunjeong; Chang, Kyeong-Ok & William C., Groutas. (2012).Potent Inhibition of Norovirus 3CL Protease by Peptidyl α-Ketoamides and α-Ketoheterocycles. Bioorganic & Medicinal Chemistry Letters, Available online 26 May 2012
    Abstract
    A series of structurally-diverse α-ketoamides and α-ketoheterocycles was synthesized and subsequently investigated for inhibitory activity against norovirus 3CL protease in vitro, as well as anti-norovirus activity in a cell-based replicon system. The synthesized compounds were found to inhibit norovirus 3CL protease in vitro and to also exhibit potent anti-norovirus activity in a cell-based replicon system.
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    URI
    http://hdl.handle.net/10057/5111
    http://dx.doi.org/10.1016/j.bmcl.2012.05.055
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