Potent inhibition of norovirus 3CL protease by peptidyl α-ketoamides and α-ketoheterocycles
Mandadapu, Sivakoteswara Rao
Weerawarna, Pathum M.
Gunnam, Mallikarjuna Reddy
Alliston, Kevin R.
Lushington, Gerald H.
Groutas, William C.
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Mandadapu, Sivakoteswara Rao; Weerawarna, Pathum M. ; Gunnam, Mallikarjuna Reddy; Alliston, Kevin R.; Lushington, Gerald H.; Kim, Yunjeong; Chang, Kyeong-Ok & William C., Groutas. (2012).Potent Inhibition of Norovirus 3CL Protease by Peptidyl α-Ketoamides and α-Ketoheterocycles. Bioorganic & Medicinal Chemistry Letters, Available online 26 May 2012
A series of structurally-diverse α-ketoamides and α-ketoheterocycles was synthesized and subsequently investigated for inhibitory activity against norovirus 3CL protease in vitro, as well as anti-norovirus activity in a cell-based replicon system. The synthesized compounds were found to inhibit norovirus 3CL protease in vitro and to also exhibit potent anti-norovirus activity in a cell-based replicon system.
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