dc.contributor.author | Lane, Meghan L. | |
dc.contributor.author | Santana, Omar | |
dc.contributor.author | Frost, Chelsea D. | |
dc.contributor.author | Nguyen, Jennifer P. | |
dc.contributor.author | Guerrero, Jennifer | |
dc.contributor.author | Skelton, William P. | |
dc.contributor.author | Skelton, Michelle | |
dc.contributor.author | Vesely, David L. | |
dc.date.accessioned | 2012-04-16T17:48:18Z | |
dc.date.available | 2012-04-16T17:48:18Z | |
dc.date.issued | 2012-03 | |
dc.identifier.citation | Lane M.L., Santana O., Frost C.D., Guerrero J., Skelton M., et al. 2012. "Cardiac hormones are c-Jun-N-terminal kinase 2-inhibiting peptides". Anticancer Research. 32 (3): 721-725 | en_US |
dc.identifier.issn | 0250-7005 | |
dc.identifier.issn | 1791-7530 | |
dc.identifier.other | WOS: 000301619200001 | |
dc.identifier.uri | http://hdl.handle.net/10057/5077 | |
dc.description | Full text of this article is not available in SOAR. | en_US |
dc.description.abstract | Background: Four cardiac peptide hormones, namely vessel dilator, long-acting natriuretic peptide (LANP), kaliuretic peptide, and atrial natriuretic peptide (ANP) have anticancer effects. Materials and Methods: The effects of these four cardiac hormones on human c-Jun-N-terminal kinase 2 (JNK2) were examined in human small cell lung cancer and human prostate cancer cells. Results: Vessel dilator, LANP, kaliuretic peptide and ANP maximally reduced expression of JNK2 by 89%, 56%, 45%, and 28%, respectively (each at p<0.0001) in human small cell lung cancer cells. In human prostate adenocarcinoma cells, JNK2 was maximally decreased 76%, 56%, 45%, (each at p<0.0001), and 28% (p<0.01) secondary to vessel dilator, LANP, kaliuretic peptide and ANP, respectively. Conclusion: These results indicate that four cardiac hormones are significant inhibitors (by up to 89%) of JNK2 in human small cell lung cancer cells and up to 76% in human prostate adenocarcinoma cells as part of their anticancer mechanism(s) of action. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | International Institute of Anticancer Research | en_US |
dc.relation.ispartofseries | Anticancer Research;2012:, v.32, no.3 | |
dc.subject | c-Jun-N-terminal kinase 2 (JNK2) | en_US |
dc.subject | Mitogen-activated protein kinase 9 (MAPK9) | en_US |
dc.subject | Stress-activated protein kinase 1 alpha (SAPK1α) | en_US |
dc.subject | Natriuretic hormones | en_US |
dc.subject | Cardiac hormones | en_US |
dc.subject.classification | ONCOLOGY | |
dc.title | Cardiac hormones are c-Jun-N-Terminal Kinase 2-inhibiting peptides | en_US |
dc.type | Article | en_US |
dc.description.version | Peer reviewed article | |
dc.rights.holder | Copyright© 2012 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved. | |