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dc.contributor.authorLane, Meghan L.
dc.contributor.authorSantana, Omar
dc.contributor.authorFrost, Chelsea D.
dc.contributor.authorNguyen, Jennifer P.
dc.contributor.authorGuerrero, Jennifer
dc.contributor.authorSkelton, William P.
dc.contributor.authorSkelton, Michelle
dc.contributor.authorVesely, David L.
dc.identifier.citationLane M.L., Santana O., Frost C.D., Guerrero J., Skelton M., et al. 2012. "Cardiac hormones are c-Jun-N-terminal kinase 2-inhibiting peptides". Anticancer Research. 32 (3): 721-725en_US
dc.identifier.otherWOS: 000301619200001
dc.descriptionFull text of this article is not available in SOAR.en_US
dc.description.abstractBackground: Four cardiac peptide hormones, namely vessel dilator, long-acting natriuretic peptide (LANP), kaliuretic peptide, and atrial natriuretic peptide (ANP) have anticancer effects. Materials and Methods: The effects of these four cardiac hormones on human c-Jun-N-terminal kinase 2 (JNK2) were examined in human small cell lung cancer and human prostate cancer cells. Results: Vessel dilator, LANP, kaliuretic peptide and ANP maximally reduced expression of JNK2 by 89%, 56%, 45%, and 28%, respectively (each at p<0.0001) in human small cell lung cancer cells. In human prostate adenocarcinoma cells, JNK2 was maximally decreased 76%, 56%, 45%, (each at p<0.0001), and 28% (p<0.01) secondary to vessel dilator, LANP, kaliuretic peptide and ANP, respectively. Conclusion: These results indicate that four cardiac hormones are significant inhibitors (by up to 89%) of JNK2 in human small cell lung cancer cells and up to 76% in human prostate adenocarcinoma cells as part of their anticancer mechanism(s) of action.en_US
dc.publisherInternational Institute of Anticancer Researchen_US
dc.relation.ispartofseriesAnticancer Research;2012:, v.32, no.3
dc.subjectc-Jun-N-terminal kinase 2 (JNK2)en_US
dc.subjectMitogen-activated protein kinase 9 (MAPK9)en_US
dc.subjectStress-activated protein kinase 1 alpha (SAPK1α)en_US
dc.subjectNatriuretic hormonesen_US
dc.subjectCardiac hormonesen_US
dc.titleCardiac hormones are c-Jun-N-Terminal Kinase 2-inhibiting peptidesen_US
dc.description.versionPeer reviewed article
dc.rights.holderCopyright© 2012 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.

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