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dc.contributor.authorLane, Meghan L.
dc.contributor.authorSantana, Omar
dc.contributor.authorFrost, Chelsea D.
dc.contributor.authorNguyen, Jennifer P.
dc.contributor.authorGuerrero, Jennifer
dc.contributor.authorSkelton, William P.
dc.contributor.authorSkelton, Michelle
dc.contributor.authorVesely, David L.
dc.date.accessioned2012-04-16T17:48:18Z
dc.date.available2012-04-16T17:48:18Z
dc.date.issued2012-03
dc.identifier.citationLane M.L., Santana O., Frost C.D., Guerrero J., Skelton M., et al. 2012. "Cardiac hormones are c-Jun-N-terminal kinase 2-inhibiting peptides". Anticancer Research. 32 (3): 721-725en_US
dc.identifier.issn0250-7005
dc.identifier.issn1791-7530
dc.identifier.otherWOS: 000301619200001
dc.identifier.urihttp://hdl.handle.net/10057/5077
dc.descriptionFull text of this article is not available in SOAR.en_US
dc.description.abstractBackground: Four cardiac peptide hormones, namely vessel dilator, long-acting natriuretic peptide (LANP), kaliuretic peptide, and atrial natriuretic peptide (ANP) have anticancer effects. Materials and Methods: The effects of these four cardiac hormones on human c-Jun-N-terminal kinase 2 (JNK2) were examined in human small cell lung cancer and human prostate cancer cells. Results: Vessel dilator, LANP, kaliuretic peptide and ANP maximally reduced expression of JNK2 by 89%, 56%, 45%, and 28%, respectively (each at p<0.0001) in human small cell lung cancer cells. In human prostate adenocarcinoma cells, JNK2 was maximally decreased 76%, 56%, 45%, (each at p<0.0001), and 28% (p<0.01) secondary to vessel dilator, LANP, kaliuretic peptide and ANP, respectively. Conclusion: These results indicate that four cardiac hormones are significant inhibitors (by up to 89%) of JNK2 in human small cell lung cancer cells and up to 76% in human prostate adenocarcinoma cells as part of their anticancer mechanism(s) of action.en_US
dc.language.isoen_USen_US
dc.publisherInternational Institute of Anticancer Researchen_US
dc.relation.ispartofseriesAnticancer Research;2012:, v.32, no.3
dc.subjectc-Jun-N-terminal kinase 2 (JNK2)en_US
dc.subjectMitogen-activated protein kinase 9 (MAPK9)en_US
dc.subjectStress-activated protein kinase 1 alpha (SAPK1α)en_US
dc.subjectNatriuretic hormonesen_US
dc.subjectCardiac hormonesen_US
dc.subject.classificationONCOLOGY
dc.titleCardiac hormones are c-Jun-N-Terminal Kinase 2-inhibiting peptidesen_US
dc.typeArticleen_US
dc.description.versionPeer reviewed article
dc.rights.holderCopyright© 2012 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.


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