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    Cytotoxicity of release products from magnetic nanocomposites in targeted drug delivery

    Date
    2011-11-09
    Author
    Wamocha, Humphrey Lusenaka
    Misak, Heath Edward
    Song, Zheng
    Chu, H.Y.
    Chen, Y.Y.
    Asmatulu, Ramazan
    Yang, Shang-You
    Ho, J. C.
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    Citation
    Journal of biomaterials applications. 2011 Nov 9. [Epub ahead of print]
    Abstract
    The efficacy of chemotherapy can be significantly improved if the therapeutic agent remains localized at the afflicted area and released at controlled rates. Such a targeted drug delivery can be achieved using magnetic nanocomposite (MNC), which incorporates drug and magnetic nanoparticles in biodegradable polymer microspheres. Reported here are results from an in vitro study on drug release rate and cytotoxicity of other release products from MNC. The model system contains an anti-cancer chemotherapy agent 5-flurouracil (5-FU) and (Co(0.5)Zn(0.5))Fe(2)O(4) in poly(lactic-co-glycolic acid) (PLGA) matrix produced by an oil/oil emulsion technique. Cell proliferation data indicate a sustained release of 5-FU for mouse macrophage cell eradication, whereas other microsphere components of magnetic nanoparticles and PLGA have little cytotoxic effects.
    Description
    Click on the DOI link below to access the article (may not be free).
    URI
    http://dx.doi.org/10.1177/0885328211421989
    http://hdl.handle.net/10057/5008
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