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dc.contributorWichita State University. Department of Physical Therapyen_US
dc.contributor.authorSmith, Barbara S.en_US
dc.contributor.authorWalker, N. J.en_US
dc.date.accessioned2012-03-12T19:12:27Z
dc.date.available2012-03-12T19:12:27Z
dc.date.issued1990-11en_US
dc.identifier2278033en_US
dc.identifier0153257en_US
dc.identifier.citationTeratology. 1990 Nov; 42(5): 581-91.en_US
dc.identifier.issn0040-3709en_US
dc.identifier.urihttp://dx.doi.org/10.1002/tera.1420420515en_US
dc.identifier.urihttp://hdl.handle.net/10057/4783
dc.descriptionClick on the DOI link below to access the article (may not be free).en_US
dc.description.abstractThe optic cups of two gestational day 11 trisomy (ts) 1 mouse embryos and a normal littermate control were examined using transmission electron microscopy (TEM). One trisomic embryo had a small lens with a lens stalk; the other was aphakic. The resolution available with TEM allowed detailed evaluation of cell organelles, spatial relationships, and the intra- and extracellular structural environment of the optic cup in normal and abnormal mouse embryos. Differences between the normal littermate and the trisomic optic cups, as well as between the two ts 1 structures, included the following: 1) melanin granules in the retinal layer and intraretinal space as well as in the pigment layer, 2) neither pseudostratified nor cuboidal neuroepithelium in trisomic optic cups, 3) increasing cell lysis with severity of eye defect, 4) fusion between retinal and pigment layer cells and cells from the pigment layer and head mesoderm. This investigation not only confirmed some of the abnormal morphology found in light microscopic studies of ts 1 at this gestational age but also identified other anomalies in the ts 1 eye that may play a part in the dysgenesis of this organ. The roles of larger than normal intercellular lacunae, disorganized microtubules, and the connections between different cell types in the ts 1 optic cup require further investigation.en_US
dc.format.extent581-91en_US
dc.language.isoengen_US
dc.publisherJohn Wiley & Sonsen_US
dc.relation.ispartofseriesTeratologyen_US
dc.relation.ispartofseriesTeratologyen_US
dc.sourceNLMen_US
dc.subject.meshAnimalsen_US
dc.subject.meshEpithelium/drug effectsen_US
dc.subject.meshEye Abnormalities/pathologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshMiceen_US
dc.subject.meshMicroscopy, Electronen_US
dc.subject.meshPregnancyen_US
dc.subject.meshRetina/abnormalitiesen_US
dc.subject.meshTrisomyen_US
dc.subject.meshEpithelium/ultrastructureen_US
dc.subject.meshRetina/ultrastructureen_US
dc.titleUltrastructure of murine trisomy 1 optic cupen_US
dc.typeArticleen_US
dc.coverage.spacialUnited Statesen_US
dc.description.versionpeer revieweden_US
dc.rights.holderCopyright © 1990 Wiley-Lissen_US


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