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dc.contributor.authorTiew, Kok-Chuan
dc.contributor.authorDou, Dengfeng
dc.contributor.authorTeramoto, Tadahisa
dc.contributor.authorLai, Huiguo
dc.contributor.authorAlliston, Kevin R.
dc.contributor.authorLushington, Gerald H.
dc.contributor.authorPadmanabhan, Radhakrishnan
dc.contributor.authorGroutas, William C.
dc.date.accessioned2012-02-20T22:24:03Z
dc.date.available2012-02-20T22:24:03Z
dc.date.issued2012-02
dc.identifier.citationTiew, Kok-Chuan; Dou, Dengfeng; Teramoto, Tadahisa; Lai, Huiguo; Alliston, Kevin R.; Lushington, Gerald H.; Padmanabhan, R. & William C., Groutas.2012. Inhibition of Dengue virus and West Nile virus proteases by click chemistry-derived benz[d]isothiazol-3(2H)-one derivatives. Bioorganic & Medicinal Chemistry, 20 (3):1213-1221en_US
dc.identifier.issn0968-0896
dc.identifier.issn1464-3391
dc.identifier.otherWOS:000299535400006
dc.identifier.urihttp://hdl.handle.net/10057/4487
dc.identifier.urihttp://dx.doi.org/10.1016/j.bmc.2011.12.047
dc.descriptionClick on the DOI link below to access the article (may not be free).en_US
dc.description.abstractTwo click chemistry-derived focused libraries based on the benz[d]isothiazol-3(2H)-one scaffold were synthesized and screened against Dengue virus and West Nile virus NS2B-NS3 proteases. Several compounds (4l, 7j-n) displayed noteworthy inhibitory activity toward Dengue virus NS2B-NS3 protease in the absence and presence of added detergent. These compounds could potentially serve as a launching pad for a hit-to-lead optimization campaign.en_US
dc.language.isoen_USen_US
dc.publisherElsevieren_US
dc.relation.ispartofseriesBioorganic & Medicinal Chemistry;2012:, v.20, no.3
dc.subjectDengue virusen_US
dc.subjectWest Nile virusen_US
dc.subjectProteaseen_US
dc.subjectInhibitoren_US
dc.subjectClick chemistryen_US
dc.titleInhibition of Dengue virus and West Nile virus proteases by click chemistry-derived benz[d]isothiazol-3(2H)-one derivativesen_US
dc.typeArticleen_US
dc.description.versionPeer reviewed article
dc.rights.holderCopyright © 2012, Elsevier


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