Inhibition of Dengue virus and West Nile virus proteases by click chemistry-derived benz[d]isothiazol-3(2H)-one derivatives
Alliston, Kevin R.
Lushington, Gerald H.
Groutas, William C.
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Tiew, Kok-Chuan; Dou, Dengfeng; Teramoto, Tadahisa; Lai, Huiguo; Alliston, Kevin R.; Lushington, Gerald H.; Padmanabhan, R. & William C., Groutas.2012. Inhibition of Dengue virus and West Nile virus proteases by click chemistry-derived benz[d]isothiazol-3(2H)-one derivatives. Bioorganic & Medicinal Chemistry, 20 (3):1213-1221
Two click chemistry-derived focused libraries based on the benz[d]isothiazol-3(2H)-one scaffold were synthesized and screened against Dengue virus and West Nile virus NS2B-NS3 proteases. Several compounds (4l, 7j-n) displayed noteworthy inhibitory activity toward Dengue virus NS2B-NS3 protease in the absence and presence of added detergent. These compounds could potentially serve as a launching pad for a hit-to-lead optimization campaign.
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