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dc.contributorWichita State University. Department of Chemistryen_US
dc.contributor.authorTalaty, Erach R.en_US
dc.contributor.authorChueachavalit, Chawaleeen_US
dc.contributor.authorOsburn, Sandra M.en_US
dc.contributor.authorVan Stipdonk, Michael J.en_US
dc.identifier.citationRapid communications in mass spectrometry : RCM. 2007; 21(15): 2529-37.en_US
dc.descriptionClick on the DOI link below to access the article (may not be free).en_US
dc.description.abstractIn a previous study we found that a dominant fragmentation pathway observed for collision-induced dissociation (CID) of b(3)+ derived from peptides with sequence AXAG, where X is gamma-aminobutyric acid (gammaAbu) or epsilon-aminocaproic acid (Cap), involved the loss of 89 mass units (u). A neutral loss of 89 u corresponded to the free acid mass of an alanine (A) residue. This specific pathway was studied in greater detail here using a series of A(gammaAbu)AG peptides with strategic positioning of (15)N, (13)C and (2)H isotope labels. Based on the extensive labeling, several possible routes to the net elimination of 89 u are proposed. One is based on initial elimination of either aziridinone or imine and CO, followed by opening of an oxazolinone, tautomerization and elimination of H2O. Another involves formation of an aziridinone by cleavage of the N-terminal amide bond, and transfer of O and H atoms to this fragment via an H-bonded ion-molecule complex to complete the loss of 89 u. Both types of pathway include the transfer/migration of H atoms from the alpha-carbon position of gammaAbu or A residues.en_US
dc.publisherJohn Wiley and Sonsen_US
dc.relation.ispartofseriesRapid communications in mass spectrometry : RCMen_US
dc.relation.ispartofseriesRapid Commun. Mass Spectrom.en_US
dc.subjectResearch Support, Non-U.S. Gov'ten_US
dc.subjectResearch Support, U.S. Gov't, Non-P.H.S.en_US
dc.subject.meshAmino Acids/chemistryen_US
dc.subject.meshCarbon Isotopes/analysisen_US
dc.subject.meshIsotope Labeling/methodsen_US
dc.subject.meshNitrogen Isotopes/analysisen_US
dc.subject.meshPeptide Mapping/methodsen_US
dc.subject.meshSpectrometry, Mass, Electrospray Ionization/methodsen_US
dc.subject.meshgamma-Aminobutyric Acid/chemistryen_US
dc.titleInvestigation of the neutral loss of a full amino acid mass during collision-induced dissociation of the b(3)+ ion derived from a model peptide containing a 4-aminobutyric acid residueen_US
dc.description.versionpeer revieweden_US
dc.rights.holderCopyright © 2007 John Wiley & Sonsen_US

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