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    Novel fragmentation pathway for CID of (b(n) - 1 + Cat)+ ions from model, metal cationized peptides

    Date
    2005-08-01
    Author
    Cooper, Travis J.
    Talaty, Erach R.
    Van Stipdonk, Michael J.
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    Citation
    Journal of the American Society for Mass Spectrometry. 2005 Aug; 16(8): 1305-10.
    Abstract
    We report a new fragmentation pathway for the CID of (b3 - 1 + Cat)+ product ions derived from the model peptide AXAG, where X = beta-alanine, gamma-aminobutyric acid, epsilon-amino-n-caproic acid, or 4-aminomethylbenzoic acid. By changing the amino acid to the C-terminal side of the amino acid X, and incorporating 15N and 13C labeled residues at the same position, we conclude that the dissociation pathway most likely leads to a metal cationized nitrile. With respect to the various amino acids at position X, the putative nitrile product becomes more prominent, relative to the conventional (a3 - 1 + Cat)+ species, in the order beta-alanine < gamma-aminobutyric acid < epsilon-aminocaproic acid < 4-aminomethylbenzoic acid. The pathway is not observed for peptides with alpha-amino acids at position X. The product ion is observed most prominently during the CID of Li+ and Na+ cationized peptides, only to a small extent for Ag+ cationized peptides, and not at all from protonated analogues.
    Description
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    URI
    http://dx.doi.org/10.1016/j.jasms.2005.01.028
    http://hdl.handle.net/10057/4428
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