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dc.contributorWichita State University. Department of Chemistryen_US
dc.contributor.authorHe, Guijiaen_US
dc.contributor.authorDou, Dengfengen_US
dc.contributor.authorWei, Liuqingen_US
dc.contributor.authorAlliston, Kevin R.en_US
dc.contributor.authorGroutas, William C.en_US
dc.date.accessioned2012-02-06T17:17:27Z
dc.date.available2012-02-06T17:17:27Z
dc.date.issued2010-09-01en_US
dc.identifier20638756en_US
dc.identifier0420510en_US
dc.identifierS0223-5234(10)00472-1en_US
dc.identifierHL 57788/ R01 HL057788-08en_US
dc.identifier.citationEuropean journal of medicinal chemistry. 2010 Sep; 45(9): 4280-7.en_US
dc.identifier.issn1768-3254en_US
dc.identifier.issn0223-5234en_US
dc.identifier.urihttp://dx.doi.org/10.1016/j.ejmech.2010.06.028en_US
dc.identifier.urihttp://hdl.handle.net/10057/4425
dc.descriptionClick on the DOI link below to access the article.en_US
dc.description.abstractA series of compounds based on the N-amino-4-imidazolidinone scaffold was synthesized and screened against human neutrophil elastase (HNE). These studies lead to the identification of a selective, low micromolar reversible competitive inhibitor of HNE.en_US
dc.description.sponsorshipNHLBI NIH HHS/ NHLBI NIH HHSen_US
dc.format.extent4280-7en_US
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.ispartofseriesEuropean journal of medicinal chemistryen_US
dc.relation.ispartofseriesEur J Med Chemen_US
dc.sourceNLMen_US
dc.subjectResearch Support, N.I.H., Extramuralen_US
dc.subject.meshDrug Designen_US
dc.subject.meshHumansen_US
dc.subject.meshImidazolidines/chemical synthesisen_US
dc.subject.meshLeukocyte Elastase/antagonists & inhibitorsen_US
dc.subject.meshProtease Inhibitors/chemical synthesisen_US
dc.subject.meshImidazolidines/chemistryen_US
dc.subject.meshImidazolidines/pharmacologyen_US
dc.subject.meshProtease Inhibitors/chemistryen_US
dc.subject.meshProtease Inhibitors/pharmacologyen_US
dc.titleInhibitors of human neutrophil elastase based on a highly functionalized N-amino-4-imidazolidinone scaffolden_US
dc.typeArticleen_US
dc.coverage.spacialFranceen_US
dc.description.versionpeer revieweden_US
dc.rights.holderCopyright © 2010, Elsevieren_US


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