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    Inhibitors of human neutrophil elastase based on a highly functionalized N-amino-4-imidazolidinone scaffold

    Date
    2010-09-01
    Author
    He, Guijia
    Dou, Dengfeng
    Wei, Liuqing
    Alliston, Kevin R.
    Groutas, William C.
    Metadata
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    Citation
    European journal of medicinal chemistry. 2010 Sep; 45(9): 4280-7.
    Abstract
    A series of compounds based on the N-amino-4-imidazolidinone scaffold was synthesized and screened against human neutrophil elastase (HNE). These studies lead to the identification of a selective, low micromolar reversible competitive inhibitor of HNE.
    Description
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    URI
    http://dx.doi.org/10.1016/j.ejmech.2010.06.028
    http://hdl.handle.net/10057/4425
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