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dc.contributorWichita State University. Department of Chemistryen_US
dc.contributor.authorDou, Dengfengen_US
dc.contributor.authorViwanathan, Prasanthen_US
dc.contributor.authorLi, Yien_US
dc.contributor.authorHe, Guijiaen_US
dc.contributor.authorAlliston, Kevin R.en_US
dc.contributor.authorLushington, Gerald H.en_US
dc.contributor.authorBrown-Clay, Joshua D.en_US
dc.contributor.authorPadmanabhan, Radhakrishnanen_US
dc.contributor.authorGroutas, William C.en_US
dc.date.accessioned2012-02-06T17:17:18Z
dc.date.available2012-02-06T17:17:18Z
dc.date.issued2010-11-08en_US
dc.identifier20882963en_US
dc.identifier100886263en_US
dc.identifierAI577045en_US
dc.identifier.citationJournal of combinatorial chemistry. 2010 Nov 8; 12(6): 836-43.en_US
dc.identifier.issn1520-4774en_US
dc.identifier.urihttp://dx.doi.org/10.1021/cc100091hen_US
dc.identifier.urihttp://hdl.handle.net/10057/4408
dc.descriptionClick on the DOI link below to access the article.en_US
dc.description.abstractThe 1-oxo-1, 2, 3, 4-tetrahydroisoquinoline and 1-Oxo-1, 2-dihydroisoquinoline scaffolds were utilized in the design and solution phase synthesis of focused libraries of compounds for screening against West Nile Virus (WNV) protease. Exploratory studies have led to the identification of a WNV protease inhibitor (a 1-oxo-1, 2-dihydroisoquinoline-based derivative, 12j) which could potentially serve as a launching pad for a hit-to-lead optimization campaign. The identified hit was devoid of any inhibitory activity toward a panel of mammalian serine proteases.en_US
dc.description.sponsorshipNIAID NIH HHSen_US
dc.format.extent836-43en_US
dc.language.isoengen_US
dc.publisherAmerican Chemical Societyen_US
dc.relation.ispartofseriesJournal of combinatorial chemistryen_US
dc.relation.ispartofseriesJ Comb Chemen_US
dc.sourceNLMen_US
dc.subjectResearch Support, N.I.H., Extramuralen_US
dc.subject.meshAntiviral Agents/chemical synthesisen_US
dc.subject.meshDrug Designen_US
dc.subject.meshMagnetic Resonance Spectroscopyen_US
dc.subject.meshModels, Molecularen_US
dc.subject.meshMolecular Structureen_US
dc.subject.meshProtease Inhibitors/chemical synthesisen_US
dc.subject.meshTetrahydroisoquinolines/chemistryen_US
dc.subject.meshWest Nile virus/drug effectsen_US
dc.subject.meshAntiviral Agents/pharmacologyen_US
dc.subject.meshProtease Inhibitors/chemistryen_US
dc.subject.meshProtease Inhibitors/pharmacologyen_US
dc.subject.meshTetrahydroisoquinolines/pharmacologyen_US
dc.subject.meshWest Nile virus/enzymologyen_US
dc.titleDesign, synthesis, and in vitro evaluation of potential West Nile virus protease inhibitors based on the 1-oxo-1,2,3,4-tetrahydroisoquinoline and 1-oxo-1,2-dihydroisoquinoline scaffoldsen_US
dc.typeArticleen_US
dc.coverage.spacialUnited Statesen_US
dc.description.versionpeer revieweden_US
dc.rights.holderCopyright © 2010 American Chemical Societyen_US


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