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    Design, synthesis, and in vitro evaluation of potential West Nile virus protease inhibitors based on the 1-oxo-1,2,3,4-tetrahydroisoquinoline and 1-oxo-1,2-dihydroisoquinoline scaffolds

    Date
    2010-11-08
    Author
    Dou, Dengfeng
    Viwanathan, Prasanth
    Li, Yi
    He, Guijia
    Alliston, Kevin R.
    Lushington, Gerald H.
    Brown-Clay, Joshua D.
    Padmanabhan, Radhakrishnan
    Groutas, William C.
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    Citation
    Journal of combinatorial chemistry. 2010 Nov 8; 12(6): 836-43.
    Abstract
    The 1-oxo-1, 2, 3, 4-tetrahydroisoquinoline and 1-Oxo-1, 2-dihydroisoquinoline scaffolds were utilized in the design and solution phase synthesis of focused libraries of compounds for screening against West Nile Virus (WNV) protease. Exploratory studies have led to the identification of a WNV protease inhibitor (a 1-oxo-1, 2-dihydroisoquinoline-based derivative, 12j) which could potentially serve as a launching pad for a hit-to-lead optimization campaign. The identified hit was devoid of any inhibitory activity toward a panel of mammalian serine proteases.
    Description
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    URI
    http://dx.doi.org/10.1021/cc100091h
    http://hdl.handle.net/10057/4408
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