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dc.contributorWichita State University. Department of Chemistryen_US
dc.contributor.authorAnbalagan, Victoren_US
dc.contributor.authorVan Stipdonk, Michael J.en_US
dc.date.accessioned2012-02-06T17:17:06Z
dc.date.available2012-02-06T17:17:06Z
dc.date.issued2003-09-01en_US
dc.identifier14505326en_US
dc.identifier9504818en_US
dc.identifier.citationJournal of mass spectrometry : JMS. 2003 Sep; 38(9): 982-9.en_US
dc.identifier.issn1076-5174en_US
dc.identifier.urihttp://dx.doi.org/10.1002/jms.512en_US
dc.identifier.urihttp://hdl.handle.net/10057/4396
dc.descriptionClick on the DOI link below to access the article (may not be free).en_US
dc.description.abstractWe report here the generation of gas-phase complexes containing Pd(II), a ligand (deprotonated alanine, A-), and/or N-terminus derivatized peptides containing histidine as one of the amino acids. The species were produced by electrospray ionization, and their gas-phase reactions were investigated using ion-trap tandem mass spectrometry. Pd(II) forms a stable diaqua complex in the gas phase of the formula, [Pd(A-) (H(2)O)(2)]+, (where A- = deprotonated alanine) along with ternary complexes containing A- and peptide. The collision-induced dissociation (CID) patterns of the binary and ternary complexes were investigated, and the dissociation patterns for the ternary complexes suggest that: (a) the imidazole ring of the histidine side group may be the intrinsic binding site of the metal ion, and (b) the peptides fragment primarily by cleavage of the amide bond to the C-terminal side of the histidine residues. These observations are in accord with previous solution-state studies in which Pd(II) was shown to cause hydrolysis of an amide bond of a peptide at the same position.en_US
dc.format.extent982-9en_US
dc.language.isoengen_US
dc.publisherJohn Wiley and Sonsen_US
dc.relation.ispartofseriesJournal of mass spectrometry : JMSen_US
dc.relation.ispartofseriesJ Mass Spectromen_US
dc.sourceNLMen_US
dc.subjectResearch Support, Non-U.S. Gov'ten_US
dc.subjectResearch Support, U.S. Gov't, Non-P.H.S.en_US
dc.subject.meshAlanine/chemistryen_US
dc.subject.meshGases/chemistryen_US
dc.subject.meshHistidine/analysisen_US
dc.subject.meshMolecular Structureen_US
dc.subject.meshPalladium/chemistryen_US
dc.subject.meshPeptides/analysisen_US
dc.subject.meshSpectrometry, Mass, Electrospray Ionizationen_US
dc.subject.meshHistidine/chemistryen_US
dc.subject.meshPeptides/chemistryen_US
dc.titleGas-phase investigation of Pd(II)-alanine complexes with small native and derivatized peptides containing histidineen_US
dc.typeArticleen_US
dc.coverage.spacialEnglanden_US
dc.description.versionpeer revieweden_US
dc.rights.holderCopyright © 2003 John Wiley & Sons, Ltd.en_US


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