A convenient, one-step synthesis of benzyl (Ar) ureas of the type ArCH(2)NHCONHR from Ar and R(1)OCH(2)NHCONHR via ureidoalkylation
Meece, Frederick A.
Jayasinghe, Champika P.
Burns, Dennis H.
MetadataShow full item record
The Journal of organic chemistry. 2009 Apr 17; 74(8): 3156-9.
A method for the one-step C-ureidoalkylation of phenol, anisole, or aniline rings furnishing ArCH(2)NHCONHR (Ar = benzyl) products in moderate to good yields is described. With phenol ring systems, higher yields were attained when the reaction was worked up with an acidic ethanethiol addition to cleave any O-ureidoalkylation products that formed during the reaction.
Click on the DOI link below to access the article (may not be free).