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dc.contributorWichita State University. Department of Chemistryen_US
dc.contributor.authorMolesworth, Samuel P.en_US
dc.contributor.authorOsburn, Sandra M.en_US
dc.contributor.authorVan Stipdonk, Michael J.en_US
dc.date.accessioned2012-02-06T17:17:00Z
dc.date.available2012-02-06T17:17:00Z
dc.date.issued2010-06-01en_US
dc.identifier20219391en_US
dc.identifier9010412en_US
dc.identifierS1044-0305(10)00105-4en_US
dc.identifier.citationJournal of the American Society for Mass Spectrometry. 2010 Jun; 21(6): 1028-36.en_US
dc.identifier.issn1879-1123en_US
dc.identifier.issn1044-0305en_US
dc.identifier.urihttp://dx.doi.org/10.1016/j.jasms.2010.02.011en_US
dc.identifier.urihttp://hdl.handle.net/10057/4378
dc.descriptionClick on the DOI link below to access the article (may not be free).en_US
dc.description.abstractIn this study, the possible influence of acidic, basic, and amide side chains on the opening of a putative macrocyclic b ion (b(5)(+)) intermediate was investigated. Collision induced dissociation (CID) of b(5) ions was studied using a group of hexapeptides in which amino acids with the side chains of interest occupied internal sequence positions. Further experiments were performed with permuted isomers of glutamine (Q) containing peptides to probe for sequence scrambling and whether the specific sequence site of the residues influences opening of the macrocycle. Overall, the trend for (apparent) preferential/selective opening of the cyclic b(5)(+), presumably due to the side chain, followed by the loss of the amino acid with active side group is: Q > K > D > N approximately E.en_US
dc.format.extent1028-36en_US
dc.language.isoengen_US
dc.publisherSpringeren_US
dc.relation.ispartofseriesJournal of the American Society for Mass Spectrometryen_US
dc.relation.ispartofseriesJ. Am. Soc. Mass Spectrom.en_US
dc.sourceNLMen_US
dc.subjectResearch Support, Non-U.S. Gov'ten_US
dc.subjectResearch Support, U.S. Gov't, Non-P.H.S.en_US
dc.subject.meshAmino Acids/chemistryen_US
dc.subject.meshPeptides, Cyclic/chemistryen_US
dc.subject.meshProteomics/methodsen_US
dc.subject.meshSpectrometry, Mass, Electrospray Ionization/methodsen_US
dc.titleInfluence of amino acid side chains on apparent selective opening of cyclic b5 ionsen_US
dc.typeArticleen_US
dc.coverage.spacialUnited Statesen_US
dc.description.versionpeer revieweden_US
dc.rights.holderCopyright © 2010, American Society for Mass Spectrometryen_US


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