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dc.contributorWichita State University. Department of Chemistryen_US
dc.contributor.authorBulleigh, Kellisen_US
dc.contributor.authorHoward, Angelaen_US
dc.contributor.authorDo, Trangen_US
dc.contributor.authorWu, Qunen_US
dc.contributor.authorAnbalagan, Victoren_US
dc.contributor.authorVan Stipdonk, Michael J.en_US
dc.date.accessioned2012-02-06T17:16:58Z
dc.date.available2012-02-06T17:16:58Z
dc.date.issued2006-01-01en_US
dc.identifier16353129en_US
dc.identifier8802365en_US
dc.identifier.citationRapid communications in mass spectrometry : RCM. 2006; 20(2): 227-32.en_US
dc.identifier.issn0951-4198en_US
dc.identifier.urihttp://dx.doi.org/10.1002/rcm.2299en_US
dc.identifier.urihttp://hdl.handle.net/10057/4374
dc.descriptionClick on the DOI link below to access the article (may not be free).en_US
dc.description.abstractIn this study we used an isotope label, generated in situ, to investigate intramolecular proton migration or scrambling during formation of [b(2)+17+Li](+) products by collision-induced dissociation (CID) of Li(+)-cationized tripeptides. To generate the isotope label, we used a McLafferty-type rearrangement of N-terminally acetylated, C-terminal peptide tert-butyl esters in which all amide positions were exchanged with deuterium. Using a set of small, model peptides, we show that intramolecular proton scrambling occurs during CID, particularly amongst adjacent sites along a peptide backbone, on the time scales employed for low-energy collisional activation in an ion-trap mass spectrometer.en_US
dc.format.extent227-32en_US
dc.language.isoengen_US
dc.publisherJohn Wiley and Sonsen_US
dc.relation.ispartofseriesRapid communications in mass spectrometry : RCMen_US
dc.relation.ispartofseriesRapid Commun. Mass Spectrom.en_US
dc.sourceNLMen_US
dc.subjectResearch Support, Non-U.S. Gov'ten_US
dc.subjectResearch Support, U.S. Gov't, Non-P.H.S.en_US
dc.subject.meshCationsen_US
dc.subject.meshDeuteriumen_US
dc.subject.meshIsotope Labeling/methodsen_US
dc.subject.meshLithium/chemistryen_US
dc.subject.meshMass Spectrometry/methodsen_US
dc.subject.meshMetals/chemistryen_US
dc.subject.meshMotionen_US
dc.subject.meshPeptides/analysisen_US
dc.subject.meshProtonsen_US
dc.subject.meshPeptides/chemistryen_US
dc.titleInvestigation of intramolecular proton migration in a series of model, metal-cationized tripeptides using in situ generation of an isotope labelen_US
dc.typeArticleen_US
dc.coverage.spacialEnglanden_US
dc.description.versionpeer revieweden_US
dc.rights.holderCopyright © 2005 John Wiley & Sons, Ltd.en_US


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