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    Investigation of intramolecular proton migration in a series of model, metal-cationized tripeptides using in situ generation of an isotope label

    Date
    2006-01-01
    Author
    Bulleigh, Kellis
    Howard, Angela
    Do, Trang
    Wu, Qun
    Anbalagan, Victor
    Van Stipdonk, Michael J.
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    Citation
    Rapid communications in mass spectrometry : RCM. 2006; 20(2): 227-32.
    Abstract
    In this study we used an isotope label, generated in situ, to investigate intramolecular proton migration or scrambling during formation of [b(2)+17+Li](+) products by collision-induced dissociation (CID) of Li(+)-cationized tripeptides. To generate the isotope label, we used a McLafferty-type rearrangement of N-terminally acetylated, C-terminal peptide tert-butyl esters in which all amide positions were exchanged with deuterium. Using a set of small, model peptides, we show that intramolecular proton scrambling occurs during CID, particularly amongst adjacent sites along a peptide backbone, on the time scales employed for low-energy collisional activation in an ion-trap mass spectrometer.
    Description
    Click on the DOI link below to access the article (may not be free).
    URI
    http://dx.doi.org/10.1002/rcm.2299
    http://hdl.handle.net/10057/4374
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