Use of the 1,2,5-thiadiazolidin-3-one 1,1 dioxide and isothiazolidin-3-one 1,1 dioxide scaffolds in the design of potent inhibitors of serine proteinases

Date
1998-03-03
Author
Kuang, Rongze
Venkataraman, Radhika
Ruan, Sumei
Groutas, William C.
Metadata
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Citation
Bioorganic & medicinal chemistry letters. 1998 Mar 3; 8(5): 539-44.
Abstract
The attachment of a phosphate leaving group to the 1,2,5-thiadiazolidin-3-one 1,1 dioxide and isothiazolidin-3-one 1,1 dioxide scaffolds was found to yield highly potent, time-dependent inhibitors of human leukocyte elastase (HLE).
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URI
http://hdl.handle.net/10057/4357
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