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dc.contributorWichita State University. Department of Chemistryen_US
dc.contributor.authorGroutas, William C.en_US
dc.contributor.authorEpp, Jeffrey B.en_US
dc.contributor.authorVenkataraman, Radhikaen_US
dc.contributor.authorKuang, Rongzeen_US
dc.contributor.authorTruong, Tien M.en_US
dc.contributor.authorMcClenahan, Jerry J.en_US
dc.contributor.authorPrakash, Omen_US
dc.date.accessioned2012-02-06T17:16:49Z
dc.date.available2012-02-06T17:16:49Z
dc.date.issued1996-09-01en_US
dc.identifier8894097en_US
dc.identifier9413298en_US
dc.identifier0968089696001332en_US
dc.identifierHL 38048en_US
dc.identifier.citationBioorganic & medicinal chemistry. 1996 Sep; 4(9): 1393-400.en_US
dc.identifier.issn0968-0896en_US
dc.identifier.urihttp://hdl.handle.net/10057/4352
dc.descriptionFull text of this article is not available in SOAR.en_US
dc.description.abstractThe inhibitory activity toward human leukocyte elastase (HLE), cathepsin G (Cat G), and proteinase 3 (PR 3) of a series of saccharin derivatives having a sulfinate leaving group was investigated. The results of this study revealed that (a) inhibitory activity is dependent on the nature and pKa of the leaving group, and (b) the synthesized saccharin derivatives exhibit selective inhibition toward HLE and PR 3, with low or no activity toward cathepsin G. The results of exploratory biochemical, HPLC and high-field 13C NMR studies are also described.en_US
dc.description.sponsorshipNHLBI NIH HHSen_US
dc.format.extent1393-400en_US
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.ispartofseriesBioorganic & medicinal chemistryen_US
dc.relation.ispartofseriesBioorg. Med. Chem.en_US
dc.sourceNLMen_US
dc.subjectResearch Support, Non-U.S. Gov'ten_US
dc.subjectResearch Support, U.S. Gov't, P.H.S.en_US
dc.subject.meshAutoantigens/immunologyen_US
dc.subject.meshCathepsin Gen_US
dc.subject.meshCathepsins/antagonists & inhibitorsen_US
dc.subject.meshChromatography, High Pressure Liquiden_US
dc.subject.meshHumansen_US
dc.subject.meshKineticsen_US
dc.subject.meshLeukocyte Elastase/antagonists & inhibitorsen_US
dc.subject.meshMagnetic Resonance Spectroscopyen_US
dc.subject.meshModels, Molecularen_US
dc.subject.meshMyeloblastinen_US
dc.subject.meshProtease Inhibitors/pharmacologyen_US
dc.subject.meshSerine Endopeptidases/metabolismen_US
dc.subject.meshStructure-Activity Relationshipen_US
dc.subject.meshSulfones/antagonists & inhibitorsen_US
dc.titleDesign, synthesis, and in vitro inhibitory activity toward human leukocyte elastase, cathepsin G, and proteinase 3 of saccharin-derived sulfones and congenersen_US
dc.typeArticleen_US
dc.coverage.spacialEnglanden_US
dc.description.versionpeer revieweden_US
dc.rights.holderCopyright © 1996, Elsevieren_US


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