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    Antifungal activity of a series of 1,2-benzisothiazol-3(2H)-one derivatives

    Date
    2011-10-01
    Author
    Dou, Dengfeng
    Alex, Deepu
    Du, Bingfan
    Tiew, Kok-Chuan
    Aravapalli, Sridhar
    Mandadapu, Sivakoteswara Rao
    Calderone, Richard
    Groutas, William C.
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    Citation
    Bioorganic & medicinal chemistry. 2011 Oct 1; 19(19): 5782-7.
    Abstract
    A series of broad-spectrum antifungal agents based on the 1,2-benzisothiazol-3(2H)-one scaffold is reported. Preliminary structure-activity relationship studies have established the importance of the presence of the heterocyclic ring, a methyl group, and a phenyl ring for optimal manifestation of antifungal activity.
    Description
    Click on the DOI link below to access the article (may not be free).
    URI
    http://dx.doi.org/10.1016/j.bmc.2011.08.029
    http://hdl.handle.net/10057/4334
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