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dc.contributorWichita State University. Department of Chemistryen_US
dc.contributor.authorOsburn, Sandra M.en_US
dc.contributor.authorOchola, Sila O.en_US
dc.contributor.authorTalaty, Erach R.en_US
dc.contributor.authorVan Stipdonk, Michael J.en_US
dc.identifier.citationRapid communications in mass spectrometry : RCM. 2007; 21(21): 3409-19.en_US
dc.descriptionClick on the DOI link below to access the article (may not be free).en_US
dc.description.abstractFormation of [bn+17+cat]+ is a prominent collision-induced dissociation (CID) pathway for Li+- and Na+-cationized peptides. Dissociation of protonated and Ag+-cationized peptides instead favors formation of the rival bn+/[bn-1+cat]+ species. In this study the influence of a 4-aminomethylbenzoic acid (4AMBz) residue on the relative intensities of [b(3)-1+cat]+ and [b(3)+17+cat]+ fragment ions was investigated using several model tetrapeptides including those with the general formula A(4AMBz)AX and A(4AMBz)GX (where X=G, A, V). For Li+- and Na+-cationized versions of the peptides there was a significant increase in the intensity of [b(3)-1+cat]+ for the peptides that contain the 4AMBz residue, and in some cases the complete elimination of the [b(3)+17+cat]+ pathway. The influence of the 4AMBz residue may be attributed to the fact that [b(3)-1+cat]+ would be a highly conjugated species containing an aromatic ring substituent. Comparison of CID profiles generated from Na+-cationized AAGV and A(4AMBz)GV suggests an apparent decrease in the critical energy for generation of [b(3)-1+Na]+ relative to that of [b(3)+17+Na]+ when the aromatic amino acid occupies a position such that it leads to the formation of the highly conjugated oxazolinone, thus leading to an increase in formation rate for the former compared to the latter.en_US
dc.publisherJohn Wiley and Sonsen_US
dc.relation.ispartofseriesRapid communications in mass spectrometry : RCMen_US
dc.relation.ispartofseriesRapid Commun. Mass Spectrom.en_US
dc.subjectResearch Support, Non-U.S. Gov'ten_US
dc.subjectResearch Support, U.S. Gov't, Non-P.H.S.en_US
dc.subject.mesh4-Aminobenzoic Acid/analogs & derivativesen_US
dc.subject.meshAmino Acid Sequenceen_US
dc.subject.meshAntifibrinolytic Agents/chemistryen_US
dc.subject.meshLithium Compounds/chemistryen_US
dc.subject.meshMolecular Sequence Dataen_US
dc.subject.meshSequence Analysis, Proteinen_US
dc.subject.meshSilver Compounds/chemistryen_US
dc.subject.meshSodium Compounds/chemistryen_US
dc.subject.meshSpectrometry, Mass, Electrospray Ionization/methodsen_US
dc.subject.mesh4-Aminobenzoic Acid/chemistryen_US
dc.titleInfluence of a 4-aminomethylbenzoic acid residue on competitive fragmentation pathways during collision-induced dissociation of metal-cationized peptidesen_US
dc.description.versionpeer revieweden_US
dc.rights.holderCopyright © 2007 John Wiley & Sons, Ltd.en_US

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