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dc.contributorWichita State University. Department of Chemistryen_US
dc.contributor.authorWei, Liuqingen_US
dc.contributor.authorGan, Xiangdongen_US
dc.contributor.authorZhong, Jiayingen_US
dc.contributor.authorAlliston, Kevin R.en_US
dc.contributor.authorGroutas, William C.en_US
dc.date.accessioned2012-02-06T17:16:31Z
dc.date.available2012-02-06T17:16:31Z
dc.date.issued2003-11-17en_US
dc.identifier14604678en_US
dc.identifier9413298en_US
dc.identifierS0968089603006175en_US
dc.identifierHL57788en_US
dc.identifier.citationBioorganic & medicinal chemistry. 2003 Nov 17; 11(23): 5149-53.en_US
dc.identifier.issn0968-0896en_US
dc.identifier.urihttp://hdl.handle.net/10057/4329
dc.descriptionFull text of this article is not available in SOAR.en_US
dc.description.abstractA central problem associated with the design of enzyme inhibitors in general, and serine protease inhibitors in particular, is the identification of templates capable of binding to the active site of an enzyme in a predictable and substrate-like fashion, orienting appended recognition elements in a correct spatial relationship so that favorable binding interactions with multiple sites are achieved. Described herein for the first time is the design of noncovalent inhibitors of human leukocyte elastase that employs a functionalized 4-imidazolidinone scaffold.en_US
dc.description.sponsorshipNHLBI NIH HHSen_US
dc.format.extent5149-53en_US
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.ispartofseriesBioorganic & medicinal chemistryen_US
dc.relation.ispartofseriesBioorg. Med. Chem.en_US
dc.sourceNLMen_US
dc.subjectResearch Support, Non-U.S. Gov'ten_US
dc.subjectResearch Support, U.S. Gov't, P.H.S.en_US
dc.subject.meshEnzyme Inhibitors/chemical synthesisen_US
dc.subject.meshHumansen_US
dc.subject.meshImidazoles/chemical synthesisen_US
dc.subject.meshLeukocyte Elastase/antagonists & inhibitorsen_US
dc.subject.meshMagnetic Resonance Spectroscopyen_US
dc.subject.meshEnzyme Inhibitors/chemistryen_US
dc.subject.meshEnzyme Inhibitors/pharmacologyen_US
dc.subject.meshImidazoles/chemistryen_US
dc.subject.meshImidazoles/pharmacologyen_US
dc.titleNoncovalent inhibitors of human leukocyte elastase based on the 4-imidazolidinone scaffolden_US
dc.typeArticleen_US
dc.coverage.spacialEnglanden_US
dc.description.versionpeer revieweden_US
dc.rights.holderCopyright © 2003, Elsevieren_US


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