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dc.contributorWichita State University. Department of Chemistryen_US
dc.contributor.authorTiew, Kok-Chuanen_US
dc.contributor.authorHe, Guijiaen_US
dc.contributor.authorAravapalli, Sridharen_US
dc.contributor.authorMandadapu, Sivakoteswara Raoen_US
dc.contributor.authorGunnam, Mallikarjuna Reddyen_US
dc.contributor.authorAlliston, Kevin R.en_US
dc.contributor.authorLushington, Gerald H.en_US
dc.contributor.authorKim, Yunjeongen_US
dc.contributor.authorChang, Kyeong-Oken_US
dc.contributor.authorGroutas, William C.en_US
dc.date.accessioned2012-02-06T17:16:09Z
dc.date.available2012-02-06T17:16:09Z
dc.date.issued2011-09-15en_US
dc.identifier21802286en_US
dc.identifier9107377en_US
dc.identifierS0960-894X(11)00954-1en_US
dc.identifierU01AI081891en_US
dc.identifier.citationBioorganic & medicinal chemistry letters. 2011 Sep 15; 21(18): 5315-9.en_US
dc.identifier.issn1464-3405en_US
dc.identifier.issn0960-894Xen_US
dc.identifier.urihttp://dx.doi.org/10.1016/j.bmcl.2011.07.016en_US
dc.identifier.urihttp://hdl.handle.net/10057/4314
dc.descriptionClick on the DOI link below to access the article (may not be free).en_US
dc.description.abstractThe first series of peptidyl aldehyde inhibitors that incorporate in their structure a glutamine surrogate has been designed and synthesized based on the known substrate specificity of Norwalk virus 3C protease. The inhibitory activity of the compounds with the protease and with a norovirus cell-based replicon system was investigated. Members of this class of compounds exhibited noteworthy activity both in vitro and in a cell-based replicon system.en_US
dc.description.sponsorshipNIAID NIH HHSen_US
dc.format.extent5315-9en_US
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.ispartofseriesBioorganic & medicinal chemistry lettersen_US
dc.relation.ispartofseriesBioorg. Med. Chem. Lett.en_US
dc.sourceNLMen_US
dc.subjectResearch Support, N.I.H., Extramuralen_US
dc.titleDesign, synthesis, and evaluation of inhibitors of Norwalk virus 3C proteaseen_US
dc.typeArticleen_US
dc.coverage.spacialEnglanden_US
dc.description.versionpeer revieweden_US
dc.rights.holderCopyright © 2011, Elsevieren_US


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