Design, synthesis, and evaluation of inhibitors of Norwalk virus 3C protease
Mandadapu, Sivakoteswara Rao
Gunnam, Mallikarjuna Reddy
Alliston, Kevin R.
Lushington, Gerald H.
Groutas, William C.
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Bioorganic & medicinal chemistry letters. 2011 Sep 15; 21(18): 5315-9.
The first series of peptidyl aldehyde inhibitors that incorporate in their structure a glutamine surrogate has been designed and synthesized based on the known substrate specificity of Norwalk virus 3C protease. The inhibitory activity of the compounds with the protease and with a norovirus cell-based replicon system was investigated. Members of this class of compounds exhibited noteworthy activity both in vitro and in a cell-based replicon system.
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