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dc.contributorWichita State University. Department of Chemistryen_US
dc.contributor.authorGroutas, William C.en_US
dc.contributor.authorKuang, Rongzeen_US
dc.contributor.authorVenkataraman, Radhikaen_US
dc.date.accessioned2012-02-06T17:16:03Z
dc.date.available2012-02-06T17:16:03Z
dc.date.issued1994-01-14en_US
dc.identifier8292039en_US
dc.identifier0372516en_US
dc.identifierS0006291X84710485en_US
dc.identifierHL 38048en_US
dc.identifier.citationBiochemical and biophysical research communications. 1994 Jan 14; 198(1): 341-9.en_US
dc.identifier.issn0006-291Xen_US
dc.identifier.urihttp://hdl.handle.net/10057/4299
dc.descriptionFull text of this article is not available in SOAR.en_US
dc.description.abstractA series of substituted 3-oxo-1,2,5-thiadiazolidine 1,1-dioxides has been synthesized and their in vitro inhibitory activity toward human leukocyte elastase and cathepsin G was investigated. These compounds were found to inactivate the two enzymes efficiently and in a time-dependent fashion.en_US
dc.description.sponsorshipNHLBI NIH HHSen_US
dc.format.extent341-9en_US
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.ispartofseriesBiochemical and biophysical research communicationsen_US
dc.relation.ispartofseriesBiochem. Biophys. Res. Commun.en_US
dc.sourceNLMen_US
dc.subjectResearch Support, U.S. Gov't, P.H.S.en_US
dc.subject.lcshCathepsins/blooden_US
dc.subject.lcshCyclic S-Oxides/pharmacologyen_US
dc.subject.lcshPancreatic Elastase/blooden_US
dc.subject.lcshThiadiazoles/pharmacologyen_US
dc.subject.meshCathepsin Gen_US
dc.subject.meshCathepsins/antagonists & inhibitorsen_US
dc.subject.meshCyclic S-Oxides/chemical synthesisen_US
dc.subject.meshHumansen_US
dc.subject.meshKineticsen_US
dc.subject.meshLeukocyte Elastaseen_US
dc.subject.meshLeukocytes/enzymologyen_US
dc.subject.meshMolecular Structureen_US
dc.subject.meshPancreatic Elastase/antagonists & inhibitorsen_US
dc.subject.meshSerine Endopeptidasesen_US
dc.subject.meshStructure-Activity Relationshipen_US
dc.subject.meshThiadiazoles/chemical synthesisen_US
dc.subject.meshTime Factorsen_US
dc.titleSubstituted 3-oxo-1,2,5-thiadiazolidine 1,1-dioxides: a new class of potential mechanism-based inhibitors of human leukocyte elastase and cathepsin Gen_US
dc.typeArticleen_US
dc.coverage.spacialUnited Statesen_US
dc.description.versionpeer revieweden_US
dc.rights.holderCopyright © 1994, Elsevieren_US


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