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dc.contributorWichita State University. Department of Chemistryen_US
dc.contributor.authorBrubaker, Michael J.en_US
dc.contributor.authorGroutas, William C.en_US
dc.contributor.authorHoidal, John R.en_US
dc.contributor.authorRao, Narayanam V.en_US
dc.date.accessioned2012-02-06T17:15:59Z
dc.date.available2012-02-06T17:15:59Z
dc.date.issued1992-11-16en_US
dc.identifier1445363en_US
dc.identifier0372516en_US
dc.identifier0006-291X(92)91375-Zen_US
dc.identifierHL 38048en_US
dc.identifier.citationBiochemical and biophysical research communications. 1992 Nov 16; 188(3): 1318-24.en_US
dc.identifier.issn0006-291Xen_US
dc.identifier.urihttp://hdl.handle.net/10057/4290
dc.descriptionFull text of this article is not available in SOAR.en_US
dc.description.abstractA series of peptidyl thiobenzyl esters was used to map the active site of human leukocyte proteinase 3. The steady-state kinetics parameters reveal the following features regarding the substrate specificity of proteinase 3 and its putative active site: (a) the preferred P1 residue is a small hydrophobic amino acid such as aminobutyric acid, norvaline, valine or alanine (in decreasing order of preference); (b) the enzyme has an extended active site; and (c) its active site is similar to that of the related serine proteinases leukocyte elastase and leukocyte cathepsin G.en_US
dc.description.sponsorshipNHLBI NIH HHSen_US
dc.format.extent1318-24en_US
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.ispartofseriesBiochemical and biophysical research communicationsen_US
dc.relation.ispartofseriesBiochem. Biophys. Res. Commun.en_US
dc.sourceNLMen_US
dc.subjectResearch Support, U.S. Gov't, P.H.S.en_US
dc.subject.meshAmino Acid Sequenceen_US
dc.subject.meshBinding Sitesen_US
dc.subject.meshEsters/metabolismen_US
dc.subject.meshMolecular Sequence Dataen_US
dc.subject.meshMyeloblastinen_US
dc.subject.meshNeutrophils/enzymologyen_US
dc.subject.meshPeptides/metabolismen_US
dc.subject.meshPhenols/metabolismen_US
dc.subject.meshSerine Endopeptidases/metabolismen_US
dc.subject.meshSubstrate Specificityen_US
dc.subject.meshSulfhydryl Compoundsen_US
dc.titleHuman neutrophil proteinase 3: mapping of the substrate binding site using peptidyl thiobenzyl estersen_US
dc.typeArticleen_US
dc.coverage.spacialUnited Statesen_US
dc.description.versionpeer revieweden_US
dc.rights.holderCopyright © 1992, Elsevieren_US


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