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dc.contributorWichita State University. Department of Chemistryen_US
dc.contributor.authorSmucker, Bradley W.en_US
dc.contributor.authorVan Stipdonk, Michael J.en_US
dc.contributor.authorEichhorn, David M.en_US
dc.date.accessioned2012-02-06T17:15:53Z
dc.date.available2012-02-06T17:15:53Z
dc.date.issued2007-10-01en_US
dc.identifier17698201en_US
dc.identifier7905788en_US
dc.identifierS0162-0134(07)00178-Xen_US
dc.identifierP20 RR016475/ P20 RR017708/ P20 RR017708-030013/ P20 RR017708-040013en_US
dc.identifier.citationJournal of inorganic biochemistry. 2007 Oct; 101(10): 1537-42.en_US
dc.identifier.issn0162-0134en_US
dc.identifier.urihttp://dx.doi.org/10.1016/j.jinorgbio.2007.06.042en_US
dc.identifier.urihttp://hdl.handle.net/10057/4274
dc.descriptionClick on the DOI link below to access the article.en_US
dc.description.abstractThe use of 2,2'-dithiodibenzaldehyde (DTDB) as a reactant for incorporating thiolate donors into the coordination sphere of a transition metal complex without the need for protecting groups is expanded to include the synthesis of complexes with pentadentate ligands. The ligand N,N'-bis(thiosalicylideneimine)-2,2'-thiobis(ethylamine) (tsaltp) is synthesized at a cobalt center by the reaction of DTDB with a Co complex of thiobis(ethylamine). The resulting Co complexes are thus coordinated by the N(2)S(3) pentadentate ligand through two imine N atoms, two thiolate S atoms, and one thioether S atom. A dimeric, bis-thiolate-bridged complex (1) is isolated and converted to a monomeric CN adduct (2) by treatment with KCN. The N(2)S(3) coordination environment provided by the tsaltp ligand is similar to that provided by the protein donors at the active site of the nitrile hydratase enzymes, with 2 being the first octahedral Co complex reported with such a coordination sphere.en_US
dc.description.sponsorshipNCRR NIH HHS/ NCRR NIH HHS/ NCRR NIH HHS/ NCRR NIH HHSen_US
dc.format.extent1537-42en_US
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.ispartofseriesJournal of inorganic biochemistryen_US
dc.relation.ispartofseriesJ. Inorg. Biochem.en_US
dc.sourceNLMen_US
dc.subjectResearch Support, N.I.H., Extramuralen_US
dc.subjectResearch Support, U.S. Gov't, Non-P.H.S.en_US
dc.subject.meshBenzaldehydes/chemistryen_US
dc.subject.meshBinding Sitesen_US
dc.subject.meshCobalt/chemistryen_US
dc.subject.meshCrystallography, X-Rayen_US
dc.subject.meshHydro-Lyases/chemistryen_US
dc.subject.meshLigandsen_US
dc.subject.meshModels, Molecularen_US
dc.subject.meshSpectrometry, Mass, Electrospray Ionizationen_US
dc.subject.meshSpectroscopy, Fourier Transform Infrareden_US
dc.subject.meshSulfhydryl Compounds/chemistryen_US
dc.titleIncorporation of thiolate donation using 2,2'-dithiodibenzaldehyde: complexes of a pentadentate N2S3 ligand with relevance to the active site of Co nitrile hydrataseen_US
dc.typeArticleen_US
dc.coverage.spacialUnited Statesen_US
dc.description.versionpeer revieweden_US
dc.rights.holderCopyright © 2007, Elsevieren_US


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