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dc.contributorWichita State University. Department of Chemistryen_US
dc.contributor.authorMolesworth, Samuel P.en_US
dc.contributor.authorVan Stipdonk, Michael J.en_US
dc.date.accessioned2012-02-06T17:15:52Z
dc.date.available2012-02-06T17:15:52Z
dc.date.issued2010-08-01en_US
dc.identifier20219393en_US
dc.identifier9010412en_US
dc.identifierS1044-0305(10)00104-2en_US
dc.identifier.citationJournal of the American Society for Mass Spectrometry. 2010 Aug; 21(8): 1322-8.en_US
dc.identifier.issn1879-1123en_US
dc.identifier.issn1044-0305en_US
dc.identifier.urihttp://dx.doi.org/10.1016/j.jasms.2010.02.010en_US
dc.identifier.urihttp://hdl.handle.net/10057/4271
dc.descriptionClick on the DOI link below to access the article (may not be free).en_US
dc.description.abstractThere is now strong evidence for the existence of macrocyclic isomers of b(n)(+) ions, the formation and subsequent opening of which can lead to loss of sequence information from protonated peptides in multiple-stage tandem mass spectrometry experiments. In this study, the fragmentation patterns of protonated YARFLG and permuted isomers of the model peptide were investigated by collision-induced dissociation. Of interest was the potential influence of the arginine residue, and its position in the peptide sequence, on formation of the presumed macrocyclic b(5) ion isomer and potential loss of sequence information. We find that regardless of the sequence position (either internal or at the N- or C-terminus), only direct sequence ions or ions directly related to fragmentation of the arginine side chain are observed.en_US
dc.format.extent1322-8en_US
dc.language.isoengen_US
dc.publisherSpringeren_US
dc.relation.ispartofseriesJournal of the American Society for Mass Spectrometryen_US
dc.relation.ispartofseriesJ. Am. Soc. Mass Spectrom.en_US
dc.sourceNLMen_US
dc.subjectResearch Support, Non-U.S. Gov'ten_US
dc.subjectResearch Support, U.S. Gov't, Non-P.H.S.en_US
dc.subject.meshArginine/chemistryen_US
dc.subject.meshMacrocyclic Compounds/chemistryen_US
dc.subject.meshModels, Molecularen_US
dc.subject.meshPeptides/chemistryen_US
dc.subject.meshProtonsen_US
dc.subject.meshTandem Mass Spectrometry/methodsen_US
dc.titleApparent inhibition by arginine of macrocyclic b ion formation from singly charged protonated peptidesen_US
dc.typeArticleen_US
dc.coverage.spacialUnited Statesen_US
dc.description.versionpeer revieweden_US
dc.rights.holderCopyright © 2010, American Society for Mass Spectrometryen_US


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