Novel potential mechanism-based inhibitors of human leukocyte elastase and cathepsin G: derivatives of isothiazolidin-3-one
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Issue Date
1993-12-15
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Authors
Groutas, William C.
Chong, Lee S.
Venkataraman, Radhika
Advisor
Citation
Biochemical and biophysical research communications. 1993 Dec 15; 197(2): 730-9.
Abstract
A series of heterocyclic compounds designed to function as mechanism-based inhibitors of human leukocyte elastase and cathepsin G has been synthesized and their inhibitory activity was investigated. These isothiazolidin-3-one derivatives were found to be effective inhibitors of cathepsin G.
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