Initial structural studies of charged receptors that bind to inorganic phosphate anion and to an anionic phospholipid found in bacterial membranes

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Issue Date
2011-03-18
Authors
Koralegedara, Manjula B.
Aw, Hong Wai
Burns, Dennis H.
Advisor
Citation

The Journal of organic chemistry. 2011 Mar 18; 76(6): 1930-3.

Abstract

ITC titration studies of a family of bis-ammonium receptors based upon a scaffold of two bis-linked phenol rings show that several of the receptors bind to both dihydrogenphosphate and phosphatidylglycerol anions in a similar binding motif. Thermodynamic properties determined from ITC show that anion binding is entropy driven. Job plots determined from (1)H NMR clearly demonstrate that anion-receptor binding stoichiometry is dependent on the receptor's length of its bis-amine linkage.

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