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Design, synthesis and biological evaluation of succinimide derivatives as potential mechanism-based inhibitors of human leukocyte elastase, cathepsin G and proteinase 3

dc.contributorWichita State University. Department of Chemistryen_US
dc.contributor.authorGroutas, William C.en_US
dc.contributor.authorBrubaker, Michael J.en_US
dc.contributor.authorChong, Lee S.en_US
dc.contributor.authorVenkataraman, Radhikaen_US
dc.contributor.authorHuang, Heen_US
dc.contributor.authorEpp, Jeffrey B.en_US
dc.contributor.authorKuang, Rongzeen_US
dc.contributor.authorHoidal, John R.en_US
dc.date.accessioned2012-02-06T17:15:39Z
dc.date.available2012-02-06T17:15:39Z
dc.date.issued1995-04-01en_US
dc.identifier8581420en_US
dc.identifier9413298en_US
dc.identifier096808969500024Ben_US
dc.identifierHL 38048en_US
dc.identifier.citationBioorganic & medicinal chemistry. 1995 Apr; 3(4): 375-81.en_US
dc.identifier.issn0968-0896en_US
dc.identifier.urihttp://hdl.handle.net/10057/4247
dc.descriptionFull text of this article is not available in SOAR.en_US
dc.description.abstractStructure-activity relationship study and in vitro biochemical studies with human leukocyte elastase, cathepsin G and proteinase 3 were conducted using a series of succinimide derivatives.en_US
dc.description.sponsorshipNHLBI NIH HHSen_US
dc.format.extent375-81en_US
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.ispartofseriesBioorganic & medicinal chemistryen_US
dc.relation.ispartofseriesBioorg. Med. Chem.en_US
dc.sourceNLMen_US
dc.subjectResearch Support, Non-U.S. Gov'ten_US
dc.subjectResearch Support, U.S. Gov't, P.H.S.en_US
dc.subject.lcshEnzyme Inhibitors/chemistryen_US
dc.subject.lcshEnzyme Inhibitors/pharmacologyen_US
dc.subject.lcshSuccinimides/chemistryen_US
dc.subject.lcshSuccinimides/pharmacologyen_US
dc.subject.meshAmino Acids/chemistryen_US
dc.subject.meshCathepsin Gen_US
dc.subject.meshCathepsins/antagonists & inhibitorsen_US
dc.subject.meshDrug Designen_US
dc.subject.meshEnzyme Inhibitors/chemical synthesisen_US
dc.subject.meshHumansen_US
dc.subject.meshLeukocyte Elastaseen_US
dc.subject.meshMyeloblastinen_US
dc.subject.meshPancreatic Elastase/antagonists & inhibitorsen_US
dc.subject.meshSerine Endopeptidases/drug effects*en_US
dc.subject.meshSerine Proteinase Inhibitors/pharmacologyen_US
dc.subject.meshStructure-Activity Relationshipen_US
dc.subject.meshSuccinimides/chemical synthesisen_US
dc.subject.meshTime Factorsen_US
dc.titleDesign, synthesis and biological evaluation of succinimide derivatives as potential mechanism-based inhibitors of human leukocyte elastase, cathepsin G and proteinase 3en_US
dc.typeArticleen_US
dc.coverage.spacialEnglanden_US
dc.description.versionpeer revieweden_US
dc.rights.holderCopyright © 1995, Elsevieren_US


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