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dc.contributorWichita State University. Department of Chemistryen_US
dc.contributor.authorDou, Dengfengen_US
dc.contributor.authorHe, Guijiaen_US
dc.contributor.authorAlliston, Kevin R.en_US
dc.contributor.authorGroutas, William C.en_US
dc.date.accessioned2012-02-06T17:15:21Z
dc.date.available2012-02-06T17:15:21Z
dc.date.issued2011-05-15en_US
dc.identifier21511470en_US
dc.identifier9107377en_US
dc.identifierS0960-894X(10)01787-7en_US
dc.identifierHL57788en_US
dc.identifier.citationBioorganic & medicinal chemistry letters. 2011 May 15; 21(10): 3177-80.en_US
dc.identifier.issn1464-3405en_US
dc.identifier.issn0960-894Xen_US
dc.identifier.urihttp://dx.doi.org/10.1016/j.bmcl.2010.12.033en_US
dc.identifier.urihttp://hdl.handle.net/10057/4229
dc.descriptionClick on the DOI link below to access the article (may not be free).en_US
dc.description.abstractThe general strategy and rationale underlying the design of COPD therapeutics that possess protease inhibitory activity and are also capable of releasing a species that attenuates inflammation by inhibiting caspase-1, are described. The synthesis and in vitro biochemical evaluation of a dual function molecule that sequentially inhibits HNE and caspase-1 in a time-dependent manner is reported.en_US
dc.description.sponsorshipNHLBI NIH HHSen_US
dc.format.extent3177-80en_US
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.ispartofseriesBioorganic & medicinal chemistry lettersen_US
dc.relation.ispartofseriesBioorg. Med. Chem. Lett.en_US
dc.sourceNLMen_US
dc.subjectResearch Support, N.I.H., Extramuralen_US
dc.subject.meshCatalytic Domainen_US
dc.subject.meshHumansen_US
dc.subject.meshModels, Molecularen_US
dc.subject.meshMolecular Structureen_US
dc.subject.meshNeutrophils/enzymologyen_US
dc.subject.meshPancreatic Elastase/metabolismen_US
dc.subject.meshProtease Inhibitors/enzymologyen_US
dc.subject.meshPulmonary Disease, Chronic Obstructive/enzymologyen_US
dc.subject.meshTime Factors/enzymologyen_US
dc.subject.meshNeutrophils/metabolismen_US
dc.titleDual function inhibitors of relevance to chronic obstructive pulmonary diseaseen_US
dc.typeArticleen_US
dc.coverage.spacialEnglanden_US
dc.description.versionPeer reviewed
dc.rights.holderCopyright © 2011, Elsevieren_US


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