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dc.contributorWichita State University. Department of Chemistryen_US
dc.contributor.authorGroutas, William C.en_US
dc.contributor.authorChong, Lee S.en_US
dc.contributor.authorVenkataraman, Radhikaen_US
dc.contributor.authorEpp, Jeffrey B.en_US
dc.contributor.authorKuang, Rongzeen_US
dc.contributor.authorHouser-Archield, Nadeneen_US
dc.contributor.authorHoidal, John R.en_US
dc.date.accessioned2012-02-06T17:15:19Z
dc.date.available2012-02-06T17:15:19Z
dc.date.issued1995-02-01en_US
dc.identifier7796053en_US
dc.identifier9413298en_US
dc.identifier0968089695000137en_US
dc.identifierHL 37615/ HL 38048en_US
dc.identifier.citationBioorganic & medicinal chemistry. 1995 Feb; 3(2): 187-93.en_US
dc.identifier.issn0968-0896en_US
dc.identifier.urihttp://hdl.handle.net/10057/4225
dc.descriptionFull text of this article is not available in SOAR.en_US
dc.description.abstractThe results of a structure-activity relationship study focusing on the interaction of a series of phthalimide and saccharin derivatives with leukocyte elastase, cathepsin G and proteinase 3 are described. The phthalimide derivatives were found to be inactive while some of the saccharin derivatives were found to be fair inhibitors of these enzymes.en_US
dc.description.sponsorshipNHLBI NIH HHS/ NHLBI NIH HHSen_US
dc.format.extent187-93en_US
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.ispartofseriesBioorganic & medicinal chemistryen_US
dc.relation.ispartofseriesBioorg. Med. Chem.en_US
dc.sourceNLMen_US
dc.subjectResearch Support, Non-U.S. Gov'ten_US
dc.subjectResearch Support, U.S. Gov't, P.H.S.en_US
dc.subject.lcshPhthalimides/chemistryen_US
dc.subject.lcshPhthalimides/pharmacologyen_US
dc.subject.lcshSaccharin/chemical synthesisen_US
dc.subject.lcshSaccharin/chemistryen_US
dc.subject.lcshSaccharin/pharmacologyen_US
dc.subject.meshCathepsin Gen_US
dc.subject.meshCathepsins/antagonists & inhibitorsen_US
dc.subject.meshHumansen_US
dc.subject.meshLeukocyte Elastaseen_US
dc.subject.meshMagnetic Resonance Spectroscopyen_US
dc.subject.meshMyeloblastinen_US
dc.subject.meshPancreatic Elastase/antagonists & inhibitorsen_US
dc.subject.meshPhthalimides/chemical synthesisen_US
dc.subject.meshSaccharin/analogs & derivativesen_US
dc.subject.meshSerine Endopeptidases/drug effectsen_US
dc.subject.meshStructure-Activity Relationshipen_US
dc.titleThe Gabriel-Colman rearrangement in biological systems: design, synthesis and biological evaluation of phthalimide and saccharin derivatives as potential mechanism-based inhibitors of human leukocyte elastase, cathepsin G and proteinase 3en_US
dc.typeArticleen_US
dc.coverage.spacialEnglanden_US
dc.description.versionpeer revieweden_US
dc.rights.holderCopyright © 1995, Elsevieren_US


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