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dc.contributorWichita State University. Department of Chemistryen_US
dc.contributor.authorTalaty, Erach R.en_US
dc.contributor.authorVan Stipdonk, Michael J.en_US
dc.contributor.authorHague, M. J.en_US
dc.contributor.authorProvenzano, F. A.en_US
dc.contributor.authorBoese, C. A.en_US
dc.date.accessioned2012-02-06T17:15:18Z
dc.date.available2012-02-06T17:15:18Z
dc.date.issued2002-01-01en_US
dc.identifier11813308en_US
dc.identifier9504818en_US
dc.identifier10.1002/jms.242en_US
dc.identifier.citationJournal of mass spectrometry : JMS. 2002 Jan; 37(1): 31-40.en_US
dc.identifier.issn1076-5174en_US
dc.identifier.urihttp://dx.doi.org/10.1002/jms.242en_US
dc.identifier.urihttp://hdl.handle.net/10057/4224
dc.descriptionClick on the DOI link below to access the article (may not be free).en_US
dc.description.abstractThe ring opening of 1,3-di-tert-butylaziridinone by tert-butylamine and aniline was investigated by using electrospray ionization and collision-induced dissociation in an ion trap mass spectrometer in conjunction with (15)N labeling of the two amine nucleophiles. Using the MS(n) capabilities of the ion trap instrument, we were able to monitor the retention of the (15)N label through successive fragmentation steps. Both amines exhibited a remarkable degree of selectivity in that they both cleaved exclusively the 1,3-bond (the alkyl-nitrogen bond). This result is in contrast to that obtained previously with methylamine, which cleaved just the opposite bond, namely, the 1,2-bond (the acyl-nitrogen bond). These contrasting results could not have been predicted by previously published guidelines.en_US
dc.format.extent31-40en_US
dc.language.isoengen_US
dc.publisherJohn Wiley and Sonsen_US
dc.relation.ispartofseriesJournal of mass spectrometry : JMSen_US
dc.relation.ispartofseriesJ Mass Spectromen_US
dc.sourceNLMen_US
dc.titleDetermination of regioselectivity in ring opening of tert-butylaziridinones by a combination of (15)N labeling and electrospray ionization-ion trap mass spectrometryen_US
dc.typeArticleen_US
dc.coverage.spacialEnglanden_US
dc.description.versionpeer revieweden_US
dc.rights.holderCopyright © 2001 John Wiley & Sons, Ltd.en_US


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