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dc.contributorWichita State University. Department of Chemistryen_US
dc.contributor.authorGroutas, William C.en_US
dc.contributor.authorSchechter, Norman M.en_US
dc.contributor.authorHe, Shuen_US
dc.contributor.authorYu, Hongyien_US
dc.contributor.authorHuang, Pengen_US
dc.contributor.authorTu, Juanen_US
dc.date.accessioned2012-02-06T17:15:17Z
dc.date.available2012-02-06T17:15:17Z
dc.date.issued1999-08-02en_US
dc.identifier10465545en_US
dc.identifier9107377en_US
dc.identifierS0960894X99003777en_US
dc.identifierAR 42931/ HL 57788en_US
dc.identifier.citationBioorganic & medicinal chemistry letters. 1999 Aug 2; 9(15): 2199-204.en_US
dc.identifier.issn0960-894Xen_US
dc.identifier.urihttp://hdl.handle.net/10057/4222
dc.descriptionFull text of this article is not available in SOAR.en_US
dc.description.abstractA series of compounds that utilize the 1,2,5-thiadiazolidin-3-one 1,1 dioxide scaffold was synthesized and shown to be highly effective inhibitors of recombinant human skin chymase.en_US
dc.description.sponsorshipNIAMS NIH HHS/ NHLBI NIH HHSen_US
dc.format.extent2199-204en_US
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.ispartofseriesBioorganic & medicinal chemistry lettersen_US
dc.relation.ispartofseriesBioorg. Med. Chem. Lett.en_US
dc.sourceNLMen_US
dc.subjectResearch Support, Non-U.S. Gov'ten_US
dc.subjectResearch Support, U.S. Gov't, P.H.S.en_US
dc.subject.meshChymasesen_US
dc.subject.meshCyclic S-Oxides/chemical synthesisen_US
dc.subject.meshEnzyme Inhibitors/chemical synthesisen_US
dc.subject.meshHumansen_US
dc.subject.meshSerine Endopeptidases/drug effectsen_US
dc.subject.meshSkin/enzymologyen_US
dc.subject.meshStructure-Activity Relationshipen_US
dc.subject.meshThiadiazoles/chemical synthesisen_US
dc.subject.meshCyclic S-Oxides/chemistryen_US
dc.subject.meshCyclic S-Oxides/pharmacologyen_US
dc.subject.meshEnzyme Inhibitors/chemistryen_US
dc.subject.meshEnzyme Inhibitors/pharmacologyen_US
dc.subject.meshSerine Endopeptidases/metabolismen_US
dc.subject.meshThiadiazoles/chemistryen_US
dc.subject.meshThiadiazoles/pharmacologyen_US
dc.titleHuman chymase inhibitors based on the 1,2,5-thiadiazolidin-3-one 1,1 dioxide scaffolden_US
dc.typeArticleen_US
dc.coverage.spacialEnglanden_US
dc.description.versionpeer revieweden_US
dc.rights.holderCopyright © 1999, Elsevieren_US


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