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dc.contributorWichita State University. Department of Chemistryen_US
dc.contributor.authorZhong, Jiayingen_US
dc.contributor.authorGan, Xiangdongen_US
dc.contributor.authorAlliston, Kevin R.en_US
dc.contributor.authorLai, Zhongen_US
dc.contributor.authorYu, Hongyien_US
dc.contributor.authorGroutas, Christopher S.en_US
dc.contributor.authorWong, Tzutshinen_US
dc.contributor.authorGroutas, William C.en_US
dc.date.accessioned2012-02-06T17:15:15Z
dc.date.available2012-02-06T17:15:15Z
dc.date.issued2004-07-01en_US
dc.identifier15244417en_US
dc.identifier100886263en_US
dc.identifierHL 57788en_US
dc.identifier.citationJournal of combinatorial chemistry. 2004 Jul-Aug; 6(4): 556-63.en_US
dc.identifier.issn1520-4766en_US
dc.identifier.urihttp://dx.doi.org/10.1021/cc030047ren_US
dc.identifier.urihttp://hdl.handle.net/10057/4219
dc.descriptionClick on the DOI link below to access the article (may not be free).en_US
dc.description.abstractExploratory studies related to the design and synthesis of functionalized cyclic sulfamides (I) as potential inhibitors of proteolytic enzymes were carried out. The structural motif and three diversity sites embodied in the scaffold render it amenable to combinatorial parallel synthesis and the facile generation of lead discovery prospecting libraries. The scaffold was readily assembled starting with (DL) serine methyl ester, and a series of compounds was generated and screened against human leukocyte elastase. Modification of the P(1) recognition element, believed to be accommodated at the primary specificity site (S(1) subsite) of the enzyme, yielded compounds that inhibited the enzyme by an apparent hyperbolic partial mixed-type inhibition.en_US
dc.description.sponsorshipNHLBI NIH HHSen_US
dc.format.extent556-63en_US
dc.language.isoengen_US
dc.publisherAmerican Chemical Societyen_US
dc.relation.ispartofseriesJournal of combinatorial chemistryen_US
dc.relation.ispartofseriesJ Comb Chemen_US
dc.sourceNLMen_US
dc.subjectResearch Support, Non-U.S. Gov'ten_US
dc.subjectResearch Support, U.S. Gov't, P.H.S.en_US
dc.subject.meshAmides/chemistryen_US
dc.subject.meshHumansen_US
dc.subject.meshHydrogen Bondingen_US
dc.subject.meshHydrophobic and Hydrophilic Interactionsen_US
dc.subject.meshLeukocyte Elastase/antagonists & inhibitorsen_US
dc.subject.meshMolecular Conformationen_US
dc.subject.meshMolecular Structureen_US
dc.subject.meshProtease Inhibitors/chemical synthesisen_US
dc.subject.meshSulfides/chemistryen_US
dc.subject.meshLeukocyte Elastase/metabolismen_US
dc.subject.meshProtease Inhibitors/chemistryen_US
dc.titlePotential protease inhibitors based on a functionalized cyclic sulfamide scaffolden_US
dc.typeArticleen_US
dc.coverage.spacialUnited Statesen_US
dc.description.versionpeer revieweden_US
dc.rights.holderCopyright © 2004 American Chemical Societyen_US


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