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dc.contributor.authorMcDonald, J. Daviden_US
dc.identifier.citationProceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). 1995 Sep; 209(4): 303-8.en_US
dc.descriptionClick on the link below to access the article (may not be free).en_US
dc.description.abstractA valuable approach to investigating a biological process is to study the effect of mutations in the involved genes. By studying a diverse set of such mutations, one can gain important insights into the roles that the given gene product plays in the biological process. Although this approach has long been recognized, the scarcity of mammalian mutations has largely limited such investigations to simple organisms. It has recently been shown that highly efficient mutagenesis of the mouse germline with a random point mutagen can produce mutations that are valuable in several important ways. First, it can produce numerous different types of mutations. Second, it can be used to mutate genes that have yet to be cloned or characterized. Genes that have been marked by mutation can ultimately yield molecular access after mapping to high resolution and cloning from map position. Such new investigative capabilities will ultimately allow one to gain intimate knowledge of the molecular basis of complex biological processes like behavior and development. Third, mutations can be induced that yield animal models of human heritable diseases. Such disease models allow for intensive research into the etiology of the given disease and also permit the facile evaluation of new therapeutic regimens.en_US
dc.publisherRoyal Society of Medicine Pressen_US
dc.relation.ispartofseriesProceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)en_US
dc.subject.meshBehavior, Animalen_US
dc.subject.meshDisease Models, Animalen_US
dc.subject.meshEmbryonic and Fetal Development/geneticsen_US
dc.subject.meshGenetic Diseases, Inborn/geneticsen_US
dc.subject.meshGerm-Line Mutationen_US
dc.titleUsing high-efficiency mouse germline mutagenesis to investigate complex biological phenomena: genetic diseases, behavior, and developmenten_US
dc.description.versionpeer revieweden_US
dc.rights.holderCopyright © 2008 Society for Experimental Biology and Medicineen_US

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