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dc.contributor.authorHendry, William J. IIIen_US
dc.contributor.authorSheehan, Daniel M.en_US
dc.contributor.authorKhan, Shafiq A.en_US
dc.contributor.authorMay, Jeffrey V.en_US
dc.date.accessioned2012-01-24T17:49:54Z
dc.date.available2012-01-24T17:49:54Z
dc.date.issued2002-10en_US
dc.identifier12324652en_US
dc.identifierCA60250/ ES10232/ HD37835/ HD37971en_US
dc.identifier100973463en_US
dc.identifier.citationExperimental biology and medicine (Maywood, N.J.). 2002 Oct; 227(9): 709-23.en_US
dc.identifier.issn1535-3702en_US
dc.identifier.issn1535-3699en_US
dc.identifier.urihttp://ebm.rsmjournals.com/content/227/9/709.full.pdf+html
dc.identifier.urihttp://hdl.handle.net/10057/4202
dc.descriptionClick on the link below to access the article (may not be free).en_US
dc.description.abstractAt the biomedical, regulatory, and public level, considerable concern surrounds the concept that inappropriate exposure to endocrine-disrupting chemicals, especially during the prenatal and/or neonatal period, may disrupt normal reproductive tract development and adult function. The intent of this review was to 1. Describe some unique advantages of the hamster for perinatal endocrine disruptor (ED) studies, 2. Summarize the morphological and molecular consequences of exposure to the established perinatal ED, diethylstilbestrol, in the female and male hamster, 3. Present some new, histomorphological insight into the process of neonatal diethylstilbestrol-induced disruption in the hamster uterus, and 4. Introduce recent efforts and future plans to evaluate the potency and mechanism of action of other putative EDs in the hamster experimental system. Taken together, the findings indicate that the hamster represents a unique and sensitive in vivo system to probe the phenomenon of endocrine disruption. The spectrum of candidate endpoints includes developmental toxicity, neoplasia, and more subtle endpoints of reproductive dysfunction.en_US
dc.description.sponsorshipNCI NIH HHS/ NIEHS NIH HHS/ NICHD NIH HHS/ NICHD NIH HHSen_US
dc.language.isoengen_US
dc.publisherRoyal Society of Medicine Press Ltd.en_US
dc.relation.ispartofseriesExperimental biology and medicine (Maywood, N.J.)en_US
dc.sourceNLMen_US
dc.subjectResearch Support, Non-U.S. Gov'ten_US
dc.subjectResearch Support, U.S. Gov't, Non-P.H.S.en_US
dc.subjectResearch Support, U.S. Gov't, P.H.S.en_US
dc.subjectReviewen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCricetinaeen_US
dc.subject.meshDiethylstilbestrol/pharmacologyen_US
dc.subject.meshEndocrine System/drug effectsen_US
dc.subject.meshEnvironmental Exposureen_US
dc.subject.meshEstrogens, Non-Steroidal/pharmacologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshFetus/drug effectsen_US
dc.subject.meshMaleen_US
dc.subject.meshMesocricetusen_US
dc.subject.meshModels, Animalen_US
dc.subject.meshOvary/drug effectsen_US
dc.subject.meshUterus/pathologyen_US
dc.subject.meshOvary/transplantationen_US
dc.subject.meshUterus/pathologyen_US
dc.subject.meshUterus/ultrastructureen_US
dc.titleDeveloping a laboratory animal model for perinatal endocrine disruption: the hamster chroniclesen_US
dc.typeArticleen_US
dc.description.versionpeer revieweden_US
dc.rights.holderCopyright © 2008 Society for Experimental Biology and Medicineen_US


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