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dc.contributor.authorLydy, Michael J.en_US
dc.contributor.authorLinck, S. L.en_US
dc.date.accessioned2012-01-24T17:49:41Z
dc.date.available2012-01-24T17:49:41Z
dc.date.issued2003-10en_US
dc.identifier14674587en_US
dc.identifier0357245en_US
dc.identifier.citationArchives of environmental contamination and toxicology. 2003 Oct; 45(3): 343-9.en_US
dc.identifier.issn0090-4341en_US
dc.identifier.urihttp://dx.doi.org/10.1007/s00244-002-0218-y
dc.identifier.urihttp://hdl.handle.net/10057/4196
dc.descriptionClick on the DOI link below to access the article (may not be free).en_US
dc.description.abstractA standard Organization for Economic Cooperation and Development (OECD) filter paper test was used to assess the acute toxicity of chlorpyrifos, atrazine, cyanazine, and simazine to the earthworm Eisenia fetida. Acute toxicity of chlorpyrifos was also determined in combination with the three-triazine herbicides. Surprisingly, atrazine and cyanazine caused mortality at concentrations lower than chlorpyrifos. Atrazine and cyanazine also increased the toxicity of chlorpyrifos 7.9- and 2.2-fold, respectively. However, simazine caused no toxicity to the worms and did not affect chlorpyrifos toxicity in binary mixture experiments. Possible mechanisms for the greater-than-additive toxicity for the binary combinations of atrazine and cyanazine with chlorpyrifos were investigated, including changes in uptake and biotransformation rates of chlorpyrifos in the presence of atrazine. Uptake of chlorpyrifos into the worms decreased slightly when atrazine was present in the system, therefore eliminating increased uptake as a possible explanation for the increased toxicity. Body residue analysis of worms indicated increased metabolite formation, suggesting the greater-than-additive response may be due to increased biotransformation to more toxic oxon metabolites.en_US
dc.language.isoengen_US
dc.publisherSpringer New Yorken_US
dc.relation.ispartofseriesArchives of environmental contamination and toxicologyen_US
dc.sourceNLMen_US
dc.subjectResearch Support, U.S. Gov't, Non-P.H.S.en_US
dc.subject.meshAnimalsen_US
dc.subject.meshChlorpyrifos/pharmacokineticsen_US
dc.subject.meshDrug Interactionsen_US
dc.subject.meshHerbicides/pharmacokineticsen_US
dc.subject.meshInsecticides/toxicityen_US
dc.subject.meshLethal Dose 50en_US
dc.subject.meshOligochaeta/physiologyen_US
dc.subject.meshSoil Pollutants/pharmacokineticsen_US
dc.subject.meshTissue Distributionen_US
dc.subject.meshTriazinesen_US
dc.subject.meshChlorpyrifos/toxicityen_US
dc.subject.meshHerbicides/toxicityen_US
dc.subject.meshInsecticides/toxicityen_US
dc.subject.meshSoil Pollutants/toxicityen_US
dc.titleAssessing the impact of triazine herbicides on organophosphate insecticide toxicity to the earthworm Eisenia fetidaen_US
dc.typeArticleen_US
dc.description.versionpeer revieweden_US
dc.rights.holderCopyright © 2003, Springer New Yorken_US


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