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    Linkage analysis of the hph-1 mutation and the GTP cyclohydrolase I structural gene

    Date
    1999-09
    Author
    Montañez, Cindy S.
    McDonald, J. David
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    Citation
    Molecular genetics and metabolism. 1999 Sep; 68(1): 91-2.
    Abstract
    Our research establishes genetic linkage between the hph-1 mutation and the GTP-CH I structural gene. Our results indicate that these two loci are within an 8 cM region with 95% confidence. This finding lends additional support for the use of the hph-1 mouse mutant as a bona fide model system for the human disorder GTP-CH I to further our understanding of the molecular mechanisms involved in the disease pathology of GTP-CH I deficiency.
    Description
    Click on the DOI link below to access the article (may not be free).
    URI
    http://dx.doi.org/10.1006/mgme.1999.2887
    http://hdl.handle.net/10057/4189
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