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dc.contributor.authorHendry, William J. IIIen_US
dc.contributor.authorDeBrot, Brian L.en_US
dc.contributor.authorZheng, Xinglongen_US
dc.contributor.authorBranham, William S.en_US
dc.contributor.authorSheehan, Daniel M.en_US
dc.date.accessioned2012-01-24T17:49:06Z
dc.date.available2012-01-24T17:49:06Z
dc.date.issued1999-07en_US
dc.identifier10377036en_US
dc.identifierCA60250en_US
dc.identifier0207224en_US
dc.identifier.citationBiology of reproduction. 1999 Jul; 61(1): 91-100.en_US
dc.identifier.issn0006-3363en_US
dc.identifier.urihttp://www.biolreprod.org/content/61/1/91.full
dc.identifier.urihttp://hdl.handle.net/10057/4156
dc.descriptionClick on the link below to access the article (may not be free).en_US
dc.description.abstractThe synthetic estrogen diethylstilbestrol (DES) is a potent neonatal endocrine disruptor in the hamster. To test the specificity of this phenomenon, newborn animals were treated with 100 microgram of either DES or the natural estrogen, estradiol-17beta (E2). Of the two, neonatal DES exposure caused greater morphological disruption throughout the female reproductive tract in prepubertal animals and in adults that either retained their ovaries or were ovariectomized and then given the same levels of chronic E2 stimulation. In the uterus, a characteristic histopathological profile, including enhancement of both hyperplastic and apoptotic activity, was initiated prepubertally and exclusively in the endometrial epithelial cell compartment from the neonatally DES-treated animals and then was promoted by E2 stimulation during adulthood. Interestingly, apoptotic activity was not detected in an area of endometrial epithelium that progressed to the neoplastic state in a DES-exposed animal. Lastly, chronic estrogen induction of lactoferrin was also restricted to the DES-exposed endometrium. We conclude that 1) DES is more active than E2 as a perinatal endocrine disruptor in the hamster and 2) this experimental system should be generally useful as a means to screen compounds for such activity and then probe their mechanism of action.en_US
dc.description.sponsorshipNCI NIH HHSen_US
dc.language.isoengen_US
dc.publisherSociety for the Study of Reproductionen_US
dc.relation.ispartofseriesBiology of reproductionen_US
dc.sourceNLMen_US
dc.subjectResearch Support, Non-U.S. Gov'ten_US
dc.subjectResearch Support, U.S. Gov't, Non-P.H.S.en_US
dc.subjectResearch Support, U.S. Gov't, P.H.S.en_US
dc.subject.meshAgingen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAnimals, Newbornen_US
dc.subject.meshCricetinaeen_US
dc.subject.meshDiethylstilbestrol/pharmacologyen_US
dc.subject.meshEndometrium/anatomy & histologyen_US
dc.subject.meshEstradiol/pharmacologyen_US
dc.subject.meshEstrogens, Non-Steroidal/pharmacologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshGenitalia, Female/anatomy & histologyen_US
dc.subject.meshImmunohistochemistryen_US
dc.subject.meshMesocricetusen_US
dc.subject.meshOvariectomyen_US
dc.subject.meshUterus/anatomy & histologyen_US
dc.subject.meshEndometrium/drug effectsen_US
dc.subject.meshGenitalia, Female/drug effectsen_US
dc.subject.meshGenitalia, Female/growth & developmenten_US
dc.subject.meshUterus/drug effectsen_US
dc.titleDifferential activity of diethylstilbestrol versus estradiol as neonatal endocrine disruptors in the female hamster (Mesocricetus auratus) reproductive tracten_US
dc.typeArticleen_US
dc.description.versionpeer revieweden_US


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