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dc.contributor.authorSarachek, Alvinen_US
dc.contributor.authorLovchik, J. A.en_US
dc.date.accessioned2012-01-24T17:49:03Z
dc.date.available2012-01-24T17:49:03Z
dc.date.issued1989en_US
dc.identifier2695616en_US
dc.identifier8503885en_US
dc.identifier.citationJournal of basic microbiology. 1989; 29(8): 527-35.en_US
dc.identifier.issn0233-111Xen_US
dc.identifier.urihttp://dx.doi.org/10.1002/jobm.3620290814
dc.identifier.urihttp://hdl.handle.net/10057/4151
dc.descriptionClick on the DOI link below to access the article (may not be free).en_US
dc.description.abstractNutritionally balanced heterokaryons of the naturally diploid, asexual yeast, Candida albicans are produced by fusing protoplasts of complementing auxotrophic strains. Spontaneous unidirectional internuclear transfers of an intact gene linkage group in established heterokaryons is demonstrated. Evidence is presented that a transfer event (i) typically involves a single chromosome which is added to the resident homologues of a recipient nucleus, (ii) can occur equally well in either direction between complementing nuclei and (iii) may encourage gene conversion at transferred loci in the recipient nucleus. The bearing of these findings on application of protoplast fusion to parasexual genetic analysis of C. albicans is discussed.en_US
dc.language.isoengen_US
dc.publisherWiley - V C H Verlag GmbH & Co. KGaAen_US
dc.relation.ispartofseriesJournal of basic microbiologyen_US
dc.sourceNLMen_US
dc.subject.meshCandida albicans/geneticsen_US
dc.subject.meshGene Conversionen_US
dc.subject.meshGenes, Fungalen_US
dc.subject.meshTransfectionen_US
dc.titleUnidirectional internuclear transfer of linked genes in heterokaryons of Candida albicansen_US
dc.typeArticleen_US
dc.description.versionpeer revieweden_US
dc.rights.holderCopyright © 1989 Wiley-VCHen_US


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