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dc.contributor.authorTaylor, Alanen_US
dc.contributor.authorObholz, Kevinen_US
dc.contributor.authorLinden, Gabrieleen_US
dc.contributor.authorSadiev, Sagypashen_US
dc.contributor.authorKlaus, Shellyen_US
dc.contributor.authorCarlson, Kecia D.en_US
dc.identifier.citationMolecular and cellular biochemistry. 1998 Jun; 183(1-2): 105-12.en_US
dc.descriptionClick on the DOI link below to access the article (may not be free).en_US
dc.description.abstractWe have characterized two abundant human cDNAs which, through Northern hybridization analysis, are selectively expressed in human sarcomeric muscle. DNA sequencing was performed and the two cDNAs were found to share sequence identity, with the exception of a 3' UTR extension present on the longer transcript. Our data suggest that the two transcripts are generated through alternative use of two poly(A) addition signals. The cDNAs encode a large open reading frame encompassing at least 435 codons. Through sequence comparisons, both at the DNA and predicted amino acid sequence level, we have been unable to find significant sequence similarity to any other characterized sequence. Consequently, we have termed this novel human sequence sarcosin. Although novel, Southern hybridization analysis demonstrated that the sarcosin sequence has been conserved in several mammalian species.en_US
dc.publisherSpringer New Yorken_US
dc.relation.ispartofseriesMolecular and cellular biochemistryen_US
dc.subjectResearch Support, Non-U.S. Gov'ten_US
dc.subjectResearch Support, U.S. Gov't, Non-P.H.S.en_US
dc.subject.meshAmino Acid Sequenceen_US
dc.subject.meshBase Sequenceen_US
dc.subject.meshConserved Sequenceen_US
dc.subject.meshCytoskeletal Proteinsen_US
dc.subject.meshDNA, Complementary/chemistryen_US
dc.subject.meshGene Expression Regulationen_US
dc.subject.meshMolecular Sequence Dataen_US
dc.subject.meshMuscle Proteins/biosynthesisen_US
dc.subject.meshMuscle, Skeletal/metabolismen_US
dc.subject.meshOrgan Specificity/geneticsen_US
dc.subject.meshSequence Analysis, DNAen_US
dc.subject.meshTranscription, Geneticen_US
dc.subject.meshMuscle Proteins/geneticsen_US
dc.subject.meshMuscle Proteins/isolation & purificationen_US
dc.titleDNA sequence and muscle-specific expression of human sarcosin transcriptsen_US
dc.description.versionpeer revieweden_US
dc.rights.holderCopyright © 1998, Springer Netherlandsen_US

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