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dc.contributor.authorSarachek, Alvinen_US
dc.contributor.authorHenderson, Lori A.en_US
dc.identifier.citationMycoses. 1991 Mar-Apr; 34(3-4): 177-82.en_US
dc.descriptionClick on the DOI link below to access the article (may not be free).en_US
dc.description.abstractThe genotoxic, antineoplastic platinum coordination complex, cisplatin (cis-diamminedichloroplatinum (II], exists as a positively charged aquated complex in water solution and as a neutral, nonaquated complex in saline solution. Candida albicans exhibited greater susceptibilities to cellular inactivation and induction of mitotic recombination when treated with the aquated rather than the nonaquated drug. The differential in responses was expressed by cells grown after treatment at 37 degrees C or at 25 degrees C, a temperature which promotes recovery from DNA damages by the yeast generally. Studies with protoplasts established that cell wall components do not influence cellular reactions to either form of the drug. However, membrane damaging antimycotic agents markedly affected responses. Pretreatments with fungistatic ketoconazole or with miconazole, under fungistatic or fungicidal conditions, enhanced cellular resistance to inactivation by aquated cisplatin: the effect was more pronounced with post-cisplatin growth at 25 degrees C than 37 degrees C. Fungicidal pretreatments with amphotericin B or miconazole greatly increased susceptibilities of surviving cells to the lethal and recombinagenic effects of nonaquated cisplatin with post-cisplatin recovery at 25 degrees C or 37 degrees C. Possible mechanisms underlying these responses and their implications for stability of C. albicans populations in cancer patients undergoing therapy with cisplatin are discussed.en_US
dc.publisherWiley-Blackwell Verlag GmbHen_US
dc.subjectResearch Support, Non-U.S. Gov'ten_US
dc.subject.meshAmphotericin B/pharmacologyen_US
dc.subject.meshCandida albicans/drug effectsen_US
dc.subject.meshCell Wall/drug effectsen_US
dc.subject.meshDrug Interactionsen_US
dc.titleModification of responses of Candida albicans to cisplatin by membrane damaging antimycotic agentsen_US
dc.description.versionpeer revieweden_US
dc.rights.holderCopyright © 1991, John Wiley and Sonsen_US

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