Browsing CHEM Faculty Publications by Subject "3CL protease"
Now showing items 1-4 of 4
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Potent inhibition of feline coronaviruses with peptidyl compounds targeting coronavirus 3C-like protease
(Elsevier, 2012-11-28)Feline coronavirus infection is common among domestic and exotic felid species and usually associated with mild or asymptomatic enteritis; however, feline infectious peritonitis (FIP) is a fatal disease of cats that is ... -
Structure-based design and synthesis of triazole-based macrocyclic inhibitors of norovirus protease: Structural, biochemical, spectroscopic, and antiviral studies
(Elsevier B.V., 2016-08-25)Outbreaks of acute gastroenteritis caused by noroviruses constitute a public health concern worldwide. To date, there are no approved drugs or vaccines for the management and prophylaxis of norovirus infections. A potentially ... -
Structure-based exploration and exploitation of the S-4 subsite of norovirus 3CL protease in the design of potent and permeable inhibitors
(Elsevier B.V., 2017-01-27)Human noroviruses are the primary cause of epidemic and sporadic acute gastroenteritis. The worldwide high morbidity and mortality associated with norovirus infections, particularly among the elderly, immunocompromised ... -
Structure-guided design of potent and permeable inhibitors of MERS coronavirus 3CL protease that utilize a piperidine moiety as a novel design element
(Elsevier, 2018-04-25)There are currently no approved vaccines or small molecule therapeutics available for the prophylaxis or treatment of Middle East Respiratory Syndrome coronavirus (MERS-CoV) infections. MERS-CoV 3CL protease is essential ...