Browsing CHEM Faculty Publications by Subject "3C-like protease"
Now showing items 1-3 of 3
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Antiviral drug discovery: norovirus proteases and development of inhibitors
(MDPI AG, Basel, Switzerland, 2019-02-25)Proteases are a major enzyme group playing important roles in a wide variety of biological processes in life forms ranging from viruses to mammalians. The aberrant activity of proteases can lead to various diseases; ... -
Characterization of amino acid substitutions in feline coronavirus 3C-like protease from a cat with feline infectious peritonitis treated with a protease inhibitor
(Elsevier, 2019-10)Feline infectious peritonitis (FIP) is a highly fatal disease caused by a virulent feline coronavirus in domestic and wild cats. We have previously reported the synthesis of potent coronavirus 3C-like protease (3CLpro) ... -
Protease inhibitors broadly effective against feline, ferret and mink coronaviruses
(Elsevier, 2018-12)Ferret and mink coronaviruses typically cause catarrhal diarrhea in ferrets and minks, respectively. In recent years, however, systemic fatal coronavirus infection has emerged in ferrets, which resembles feline infectious ...