CHEM Faculty Publications
Recent Submissions
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High-definition ion mobility/mass spectrometry with structural isotopic shifts for nominally isobaric isotopologues
(American Chemical Society, 2023-05-04)We had reported the isotopic envelopes in differential IMS (FAIMS) separations depending on the ion structure. However, this new approach to distinguish isomers was constrained by the unit-mass resolution commingling all ... -
Structure-guided design of direct-acting antivirals that exploit the gem-dimethyl effect and potently inhibit 3CL proteases of severe acute respiratory syndrome Coronavirus-2 (SARS-CoV-2) and middle east respiratory syndrome coronavirus (MERS-CoV)
(Elsevier Ltd, 2023-06-05)The high morbidity and mortality associated with SARS-CoV-2 infection, the etiological agent of COVID-19, has had a major impact on global public health. Significant progress has been made in the development of an array ... -
Thermoelectric materials
(Elsevier Ltd, 2023-01-01)In this chapter, the chemistry of the thermoelectric materials is discussed. First a basic introduction to the thermoelectrics phenomena, fundamental materials parameters, and potential device applications is provided. ... -
Two-dimensional violet phosphorus P11: A large band gap phosphorus allotrope
(American Chemical Society, 2023-03-30)The discovery of novel large band gap two-dimensional (2D) materials with good stability and high carrier mobility will innovate the next generation of electronics and optoelectronics. A new allotrope of 2D violet phosphorus ... -
In search of a COVID-19 vaccine and therapeutics
(Wichita State University, 5/11/2020)Since the emergence of severe acute respiratory syndrome coronavirus 2, SARS-CoV-2, and the end of March 2020, there have been almost 1,500,000 cases of COVID-19 and more than 90,000 deaths worldwide. There are currently ... -
Revisiting two thiophosphate compounds constituting d\(_0\) transition metal HfP\(_2\)S\(_6\) and d\(_{10}\) transition metal α-Ag\(_4\)P\(_2\)S\(_6\) as multifunctional materials for combining second harmonic generation response and photocurrent response
(The Royal Society of Chemistry, 2023-01-18)Two acentric thiophosphate compounds, HfP\(_2\)S\(_6\) and α-Ag\(_4\)P\(_2\)S\(_6\), are revisited and studied as infrared nonlinear optical materials. HfP\(_2\)S\(_6\) and α-Ag\(_4\)P\(_2\)S\(_6\) were structurally ... -
Detecting active deconjugating enzymes with genetically encoded activity-based Ubiquitin and Ubiquitin-like protein probes
(American Chemical Society, 2023-01-17)Post-translational modification of proteins by Ubiquitin (Ub) and Ubiquitin-like proteins (Ubls) can be reversed by deconjugating enzymes, which have been implicated in different pathways and associated with various human ... -
The broad antibacterial activity of a small synthetic receptor for cellular phosphatidylglycerol lipids
(Springer Link, 2023-01-09)A small receptor molecule composed of a porphyrin core with tetrakis-ammonium glycine pickets (liptin 3e) appears to target anionic phosphatidylglycerol (PG) lipid head groups through multifunctional binding-pocket ... -
Top-down ion mobility separations of isomeric proteoforms
(American Chemical Society, 2022-12-23)Continuing advances in proteomics highlight the ubiquity and biological importance of proteoforms proteins with varied sequence, splicing, or distribution of post-translational modifications (PTMs). The preeminent example ... -
d$^6$versus d$^{10}$, Which is better for second harmonic generation susceptibility? A Case Study of K$_2$TGe$_3$Ch$_8$ (T = Fe, Cd; Ch = S, Se)
(American Chemical Society, 2022-12-29)Two acentric chalcogenide compounds, K$_2$CdGe$_3$S$_8$ and K$_2$CdGe$_3$Se$_8$, were synthesized via conventional high-temperature solid-state reactions. The crystal structures of K$_2$CdGe$_3$S$_8$ and K$_2$CdGe$_3$S$_8$ ... -
Broad-spectrum cyclopropane-based inhibitors of coronavirus 3C-like proteases: Biochemical, structural, and virological studies
(American Chemical Society, 2022-12-28)The advent of SARS-CoV-2, the causative agent of COVID-19, and its worldwide impact on global health, have provided the impetus for the development of effective countermeasures that can be deployed against the virus, ... -
Potent protease inhibitors of highly pathogenic lagoviruses: Rabbit hemorrhagic disease virus and European brown hare syndrome virus
(American Society for Microbiology, 2022-06-29)Rabbit hemorrhagic disease (RHD) and European brown hare syndrome (EBHS) are highly contagious diseases caused by lagoviruses in the Caliciviridae family. These infectious diseases are associated with high mortality and a ... -
Structure-guided design of potent spirocyclic inhibitors of severe acute respiratory syndrome coronavirus-2 3C-like protease
(American Chemical Society, 2022-06-09)The worldwide impact of the ongoing COVID-19 pandemic on public health has made imperative the discovery and development of direct-acting antivirals aimed at targeting viral and/or host targets. SARS-CoV-2 3C-like protease ... -
Synthesis, crystal and electronic structures, nonlinear optical properties, and magnetic properties of two thiophosphates: KInP\(_2\)S\(_7\) and KCrP\(_2\)S\(_7\)
(MDPI, 2022-10-22)Two thiophosphates, KInP\(_2\)S\(_7\) and KCrP\(_2\)S\(_7\), were structurally characterized without investigating any optical properties. Herein in this work, KInP\(_2\)S\(_7\) and KCrP\(_2\)S\(_7\) were revisited to ... -
Quantitative assessment of additive leachates in abiotic weathered tire cryogrinds and its application to tire wear particles in roadside soil samples
(Elsevier Ltd, 2023-01-01)Tire and road wear particles (TRWP) are becoming an important research question with potential risks on ecological system. A comprehensive understanding of their detection and quantification in soils are challenged by the ... -
Complexometric titration of bismuth in over-the-counter stomach relief products
(ACS Publications, 2022-11-08)Three direct complexometric titration methods for bismuth subsalicylate determination in over-the-counter stomach relief caplets and liquids are presented, as well as a UV–vis assay, for use in student laboratories. The ... -
Self-assembly and micellar transition in CTAB solutions triggered by 1-Octanol
(American Chemical Society, 2022-10-13)This study exploits higher-order micellar transition ranging from ellipsoidal to rodlike to wormlike induced by 1-octanol (C$_8$OH) in an aqueous solution of cetyltrimethylammonium bromide (CTAB), characterizing phase ... -
Method development for separation and analysis of tire and road wear particles from roadside soil samples
(American Chemical Society, 2022-09-06)A comprehensive understanding of tire and road wear particles (TRWPs) and their detection and quantification in soils is still challenged by the lack of well-set standardized methods, inherent technological inconsistencies, ... -
Newly identified C–H⋯O hydrogen bond in histidine
(The Royal Society of Chemistry, 2022-06-19)New Cδ–H⋯O histidine hydrogen bonding interactions in various proteins are identified by neutron diffraction and computationally characterized. Neutron diffraction data shows several H-bond motifs with the Cδ–H moiety in ... -
Discovery of a Redox-activatable chemical probe for detection of cyclooxygenase-2 in cells and animals
(American Chemical Society, 2022-07-15)Cyclooxygenase-2 (COX-2) expression is up-regulated in inflammatory tissues and many premalignant and malignant tumors. Assessment of COX-2 protein in vivo, therefore, promises to be a powerful strategy to distinguish ...
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